N,N-Dimethyldipropylenetriamine supplier

Name
N N'-DIMETHYLDIPROPYLENETRIAMINE (ATOFI&
EINECS 234-148-4
CAS No. 10563-29-8
Article Data3
CAS DataBase
Density 0.883 g/cm³
Solubility 1000g/L at 25℃
Melting Point
Formula C₈H₂₁N₃
Boiling Point 231.176 °C at 760 mmHg
Molecular Weight 159.275
Flash Point 93.612 °C
Transport Information UN 2735 8/PG 2
Appearance
Safety 23-26-36/37/39-45
Risk Codes 21/22-34
Molecular Structure
Hazard Symbols C
Synonyms 1,3-Propanediamine,N'-(3-aminopropyl)-N,N-dimethyl- (6CI,9CI);Dipropylamine,3-amino-3'-(dimethylamino)- (7CI,8CI);1-Amino-7-(dimethylamino)-4-azaheptane;N,N-Dimethyl-N'-(g-aminopropyl)trimethylenediamine;N,N-Dimethyldipropylenetriamine;N-(3'-Dimethylaminopropyl)-1,3-diaminopropane;
PSA 41.29000
LogP 0.96770

Synthetic route

: 69852-45-5
3-[[3-(dimethylamino)propyl]amino]propionitrile

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether
With GRACE Raney 2786 catalyst; supported palladium-based catalyst In methanol at 100℃; under 22502.3 Torr; Temperature; Pressure;

: 109-55-7
1-amino-3-(dimethylamino)propane

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: LiAlH4 / diethyl ether View Scheme

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 120085-99-6
2,9‐bis(4-formylphenyl)‐1,10‐phenanthroline

: 2,9-bis{4-[(3-(3-dimethylaminopropylamino)propyl)iminomethyl]phenyl}-1,10-phenanthroline

Conditions

Conditions	Yield
In ethanol for 5h; Reflux;	98%

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 5111-07-9, 51744-55-9
purpurin-18-methyl ester

: purpurin-18-N-(N,N-dimethylpropylamino)propylimide

Conditions

Conditions	Yield
In toluene for 2h; Inert atmosphere; Reflux;	97%

: 1196055-80-7
2,5-dioxopyrrolidin-1-yl-3-((4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamido)propanoate

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 1610840-34-0
(4R)-N-(3-(3-(3-(dimethylamino)propylamino)propylamino)-3-oxopropyl)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	85%

: copper(II) nitrate trihydrate

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 1934-75-4
sodium dicyanamide

: 941582-44-1
Cu(N,N-dimethyldipropyltriamine)(dicyanamide)2

Conditions

Conditions	Yield
In water aq. soln. of sodium dicyanoamide added to preheated aq. soln. of Cu(NO3)2*3H2O and amine, heated on steam-bath for 15 min; filtered through Celite, filtrate stored at room temp. for 1 wk, ppt. filtered off, washed with 2-propanol and ether, air dried; elem. anal.;	78%

...Expand

: 13755-29-8
sodium tetrafluoroborate

: 1356855-78-1, 811431-04-6
fac-[ReI(OH2)3(CO)3](SO3CF3)

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: fac-[Re(CO)3(N,N-dimethyldipropylenetriamine)]BF4

Conditions

Conditions	Yield
In water aq. soln. of Re complex was treated with ligand; pH was adjusted to 6; MeOH was added to dissolve ppt.; refluxed for 16 h; cooled to room temp.;solid Na salt was added; kept for 2-3 d;	56%

...Expand

: 79-77-6
4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 96214-38-9
N-<3-Dimethylamino-propyl>-N'-<1-methyl-3-(2,6,6-trimethyl-cyclohexen-(1)-yl)-propyl>-1,3-propandiamin

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 100℃; under 51.7 Torr;

: 53892-69-6
(2E,4E)-4-Methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-2,4-dienal

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 96459-13-1
N-<3-Dimethylamino-propyl>-N'-<4-methyl-6-(2,6,6-trimethyl-cyclohexen-(1)-yl)-hexyl>-1,3-propandiamin

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 100℃; under 51.7 Torr;

: 127-41-3
alpha-ionone

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 96214-40-3
N-<3-Dimethylamino-propyl>-N'-<1-methyl-3-(2,6,6-trimethyl-cyclohexen-(2)-yl)-propyl>-1,3-propandiamin

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 100℃; under 51.7 Torr;

: 3155-71-3
2-methyl-4-(2,6,6-trimethylcyclohex-1-en-1-yl)-2-butenal

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 95287-26-6
N-<3-Dimethylamino-propyl>-N'-<2-methyl-4-(2,6,6-trimethyl-cyclohexen-(1)-yl)-butyl>-1,3-propandiamin

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 100℃; under 51.7 Torr;

: 87-45-6
3-isopropenyl-1-methyl-2-(3-oxobutyl)-cyclopent-1-ene

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 95008-51-8
N-<3-Dimethylamino-propyl>-N'-<1-methyl-3-(5-isopropyl-2-methyl-cyclopenten-(1)-yl)-propyl>-1,3-propandiamin

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 100℃; under 51.7 Torr;

: 53892-71-0
2,6-Dimethyl-8-<1,3,3-trimethyl-cyclohexen-(1)-yl-(2)>-octatrien-(2,4,6)-al

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 96976-73-7
N-<3-Dimethylamino-propyl>-N'-<2,6-dimethyl-8-(2,6,6-trimethyl-cyclohexen-(1)-yl)-octyl>-1,3-propandiamin

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 100℃; under 51.7 Torr;

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 6138-85-8, 52612-51-8, 52612-53-0, 60761-23-1, 64666-26-8
tetrahydroionone

: N-<3-Dimethylamino-propyl>-N'-<1-methyl-3-(2,6,6-trimethyl-cyclohexyl)-propyl>-1,3-propandiamin

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 100℃; under 51.7 Torr;

: 872054-82-5
endo-N-hydroxy-5-norbornene-2,3-dicarboximide O-bromoacetate

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 2-bromo-N-[3-(3-dimethylamino-propylamino)-propyl]-acetamide

Conditions

Conditions	Yield
In water; acetone at 20℃; for 0.266667h; Sonication;

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: C31H57N10O17P3S

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetone; H2O / 0.27 h / 20 °C / Sonication 2: aq. triethylammonium bicarbonate buffer / acetone / 1 h / 20 °C / pH 8.5 View Scheme

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 19475-69-5
N'-{3-[(3-aminopropyl)amino]propyl}-N,N-dimethylpropane-1,3-diamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: LiAlH4 / diethyl ether View Scheme

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 2-Methyl-17-amino-2,6,10,14-tetraaza-heptadecan

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: LiAlH4 / diethyl ether 3: (i) , (ii) LiAlH4, Et2O View Scheme

: C11H10BrNO4

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 2-bromo-N-[3-(3-dimethylamino-propylamino)-propyl]-acetamide

Conditions

Conditions	Yield
In water; acetone pH=10;

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 128-69-8
perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride

: 1020180-01-1
N,N'-bis[7-(dimethylamino)-4-azaheptyl]-3,4,9,10-perylenetetracarboxylic diimide

Conditions

Conditions	Yield
In 1,4-dioxane; N,N-dimethyl acetamide for 6h; Heating;

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 137076-54-1
1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid

: 1613265-63-6
C36H71N7O7

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1.5h;
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1.5h;

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 1613265-48-7
2-{[1-{4-[3-(DOTA-amino-propyl)-(3-dimethylamino-propyl)-carbamoyl]-2-isopropyl-phenyl}-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carbonyl]-amino}-adamantane-2-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h 2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h 3.1: water; lithium hydroxide / 1,4-dioxane / 5 h 3.2: pH 4 4.1: HATU; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.08 h 4.2: 25 h / 20 - 65 °C 5.1: triisobutylsilane / dichloromethane / 3.5 h / 20 °C 6.1: aq. acetate buffer / 0.5 h / 90 °C View Scheme

Yield

Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h
2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h
3.1: water; lithium hydroxide / 1,4-dioxane / 5 h
3.2: pH 4
4.1: HATU; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.08 h
4.2: 25 h / 20 - 65 °C
5.1: triisobutylsilane / dichloromethane / 3.5 h / 20 °C
6.1: aq. acetate buffer / 0.5 h / 90 °C
View Scheme

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 1613265-62-5
1-{4-[(3-DOTA(tBu)3-aminopropyl)-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl}-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h 2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h View Scheme
Multi-step reaction with 2 steps 1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h 2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.75 h View Scheme

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 1613265-64-7
1-{4-[(3-DOTA(tBu)3-aminopropyl)-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl}-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h 2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h 3.1: water; lithium hydroxide / 1,4-dioxane / 5 h 3.2: pH 4 View Scheme
Multi-step reaction with 3 steps 1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.75 h 3.1: water; lithium hydroxide / 1,4-dioxane / 5 h 3.2: pH 4 View Scheme

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 1613265-65-8
2-{[1-{4-[(3-DOTA(tBu)3-aminopropyl)-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl}-5(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino}adamantane-2-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h 2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h 3.1: water; lithium hydroxide / 1,4-dioxane / 5 h 3.2: pH 4 4.1: HATU; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.08 h 4.2: 25 h / 20 - 65 °C View Scheme
Multi-step reaction with 4 steps 1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.75 h 3.1: water; lithium hydroxide / 1,4-dioxane / 5 h 3.2: pH 4 4.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 24 h / 20 - 65 °C View Scheme

Yield

Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h
2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h
3.1: water; lithium hydroxide / 1,4-dioxane / 5 h
3.2: pH 4
4.1: HATU; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.08 h
4.2: 25 h / 20 - 65 °C
View Scheme

Multi-step reaction with 4 steps
1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h
2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.75 h
3.1: water; lithium hydroxide / 1,4-dioxane / 5 h
3.2: pH 4
4.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 24 h / 20 - 65 °C
View Scheme

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: 2-{[1-{4-[(3-DOTA-aminopropyl)-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl}-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl]amino}adamantane-2-carboxylic acid trifluoroacetate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h 2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h 3.1: water; lithium hydroxide / 1,4-dioxane / 5 h 3.2: pH 4 4.1: HATU; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.08 h 4.2: 25 h / 20 - 65 °C 5.1: triisobutylsilane / dichloromethane / 3.5 h / 20 °C View Scheme

Yield

Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h
2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h
3.1: water; lithium hydroxide / 1,4-dioxane / 5 h
3.2: pH 4
4.1: HATU; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.08 h
4.2: 25 h / 20 - 65 °C
5.1: triisobutylsilane / dichloromethane / 3.5 h / 20 °C
View Scheme

: trityl chloride polystyrene resin

: 10563-29-8
N1-(3-dimethylaminopropyl)propane-1,3-diamine

: C27H34N3Pol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane

N,N-Dimethyldipropylenetriamine Chemical Properties

N'-(3-AMINOPROPYL)-N,N-DIMETHYL-PROPANE-1,3-DIAMINE's Molecular formula: C₈H₂₁N₃
N'-(3-AMINOPROPYL)-N,N-DIMETHYL-PROPANE-1,3-DIAMINE's Molar mass: 159.27
EINECS: 234-148-4
Flash point: 220 °F
Boiling point: 220 °C(lit.)
density 0.883 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4630(lit.)
Synonyms: 3-Propanediamine, N'-(3-aminopropyl)-N,N-dimethyl-1; N,N-Dimethyldipropyltriamine; 3-Propanediamine,N'-(3-aminopropyl)-N,N-dimethyl-1; n'-(3-aminopropyl)-n,n-dimethyl-1,3-propanediamine; n'-(3-aminopropyl)-n,n-dimethyl-3-propanediamine; N N'-N,N-Dimethyldipropylenetriamine (ATOFI&; 3-(3-Dimethylaminopropylamino)propylamine; N-(3-Dimethylaminopropyl)propane-1,3-diamine; N,N-N,N-Dimethyldipropylenetriamine (ATOFINA DMAPAPA), 99%

N,N-Dimethyldipropylenetriamine Toxicity Data With Reference

1.		orl-unr LD50:1432 mg/kg		GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 28 (11)(1984),50.
2.		ipr-unr LD50:72 mg/kg		GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 28 (11)(1984),50.

3. RTECS TX7000000

N,N-Dimethyldipropylenetriamine Consensus Reports

Reported in EPA TSCA Inventory.

N,N-Dimethyldipropylenetriamine Safety Profile

A poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x.
Hazard Codes C
WGK Germany 1
RIDADR UN 2735 8/PG 2
Risk Statements 21/22-34
Safety Statements 23-26-36/37/39-45

Product Name

N N'-DIMETHYLDIPROPYLENETRIAMINE (ATOFI&

Synthetic route

N,N-Dimethyldipropylenetriamine Chemical Properties

N,N-Dimethyldipropylenetriamine Toxicity Data With Reference

N,N-Dimethyldipropylenetriamine Consensus Reports

N,N-Dimethyldipropylenetriamine Safety Profile

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