4-nitrophenol acetate
p-aminophenyl acetate
Conditions | Yield |
---|---|
With hydrogen; 5percent Pd/C In ethyl acetate at 20℃; under 2280.15 Torr; for 4h; | 100% |
With 1,1,3,3-Tetramethyldisiloxane In ethanol at 20℃; for 0.5h; Inert atmosphere; Sonication; chemoselective reaction; | 99% |
With hydrogen at 130℃; under 750.075 Torr; for 6h; chemoselective reaction; | 99% |
Conditions | Yield |
---|---|
With 50wtpercent Cs2.5H0.5PW12O40 supported on MCM-41 In acetonitrile at 50℃; for 0.5h; | 94% |
p-aminophenyl acetate
Conditions | Yield |
---|---|
With ammonium formate; magnesium In ethylene glycol for 0.0333333h; microwave irradiation; | 93% |
p-aminophenyl acetate
Conditions | Yield |
---|---|
With aluminium(III) iodide In benzene for 0.166667h; Reduction; Heating; | 92% |
With hydrazinium monoformate; zinc In methanol at 20℃; for 0.116667h; |
p-aminophenyl acetate
Conditions | Yield |
---|---|
With water at 100℃; for 3h; | 91% |
sodium hydrogen sulfate; silica gel In dichloromethane for 2h; Heating; | 90% |
With trifluoroacetic acid In dichloromethane at 20℃; for 2h; Green chemistry; | 84% |
In water at 125℃; for 2.5h; Green chemistry; | 90 %Chromat. |
4-amino-phenol
2,2'-bipyridyl-6-yl acetate
A
p-aminophenyl acetate
B
4-acetoxyacetanilide
C
<2,2'-bipyridin>-6(1H)-one
Conditions | Yield |
---|---|
With cesium fluoride In N,N-dimethyl-formamide for 0.333333h; Product distribution; Ambient temperature; other esters, reagent; | A 84% B 5% C n/a |
With cesium fluoride In N,N-dimethyl-formamide for 0.333333h; Ambient temperature; | A 84% B 5% C n/a |
Conditions | Yield |
---|---|
CoCl2 In acetonitrile for 2h; Ambient temperature; | 83% |
4-acetoxyacetanilide
A
p-aminophenyl acetate
B
4-acetaminophenol
C
4-amino-phenol
Conditions | Yield |
---|---|
In water at 150 - 200℃; Green chemistry; | A 70% B n/a C n/a |
acetic acid-(4-benzylidenamino-phenyl ester)
p-aminophenyl acetate
sulfuric acid
acetic acid-(4-benzylidenamino-phenyl ester)
A
p-aminophenyl acetate
B
benzaldehyde
Conditions | Yield |
---|---|
With 4-hydroxyacetophenone monooxygenase from P. fluorescens ACB; oxygen; NADPH In phosphate buffer at 30℃; for 1h; pH=8.0; Enzyme kinetics; Baeyer-Villiger oxidation; |
4-nitro-phenol
p-aminophenyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N; DMAP / CH2Cl2 2: H2; Pd-C / methanol View Scheme | |
Multi-step reaction with 2 steps 1: pyridine / acetone / 4 h / 20 °C / Reflux 2: iron; ammonium chloride / ethanol; water / 2 h / Reflux View Scheme |
4-benzylidenamino-phenol
p-aminophenyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH-solution; benzene 2: benzene; diluted sulfuric acid View Scheme |
Conditions | Yield |
---|---|
In 5-(Oxiran-2-yl-methoxy)-2-1(3-trifluoromethyl)phenyl]benzoxazole |
Conditions | Yield |
---|---|
Stage #1: p-aminophenol hydrochloride In tetrahydrofuran Stage #2: acetic anhydride With triethylamine In tetrahydrofuran Stage #3: With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran |
4-chlorobenzonitrile
p-aminophenyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide / water / 10 h / 140 °C / 2250.23 Torr / Autoclave 1.2: 0.5 h / 80 °C 2.1: 5% Pd/C; hydrogen / ethyl acetate / 6.5 h / 65 °C / 3750.38 Torr View Scheme |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 5℃; |
4-N-tert-butoxycarbonylaminophenol
p-aminophenyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Green chemistry 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Green chemistry View Scheme |
4-amino-phenol
p-aminophenyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol / 16 h / 100 °C / Green chemistry 2: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Green chemistry 3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Green chemistry View Scheme |
Conditions | Yield |
---|---|
With hydrazine hydrate In chloroform for 1.25h; chemoselective reaction; |
Conditions | Yield |
---|---|
With Au/Al2O3; hydrogen at 90℃; under 37503.8 Torr; Flow reactor; | A 7 %Chromat. B 86 %Chromat. |
4-Aminoacetophenone
p-aminophenyl acetate
Conditions | Yield |
---|---|
With dihydrogen peroxide In 1,4-dioxane at 100℃; Baeyer-Villiger Ketone Oxidation; |
Conditions | Yield |
---|---|
With indium(III) bromide In dichloromethane for 3h; Reflux; | 97.5% |
p-aminophenyl acetate
dimedone
4-(5,5-dimethyl-3-oxocyclohex-1-enylamino)phenyl acetate
Conditions | Yield |
---|---|
With silica-supported phosphorous pentoxide at 80℃; for 0.0666667h; Neat (no solvent); chemoselective reaction; | 95% |
With silica-supported LiHSO4 at 80℃; for 0.116667h; Neat (no solvent); | 92% |
With silica sulfuric acid at 80℃; for 0.116667h; Neat (no solvent); | 92% |
With zeolite ZSM-5 In ethanol for 0.666667h; Reflux; | 90% |
p-aminophenyl acetate
4-bromophenyl acetate
Conditions | Yield |
---|---|
Stage #1: p-aminophenyl acetate With boron trifluoride diethyl etherate; lithium bromide In acetonitrile at 0℃; for 0.166667h; Stage #2: With tert.-butylnitrite In acetonitrile at 0 - 20℃; for 1h; | 95% |
p-aminophenyl acetate
4-amino-3-bromophenyl acetate
Conditions | Yield |
---|---|
With N-Bromosuccinimide In dichloromethane at 20℃; for 20h; | 83% |
p-aminophenyl acetate
carbon monoxide
Conditions | Yield |
---|---|
With palladium(II) trifluoroacetate; C86H59F15NO2P; caesium carbonate In 1,3,5-trimethyl-benzene at 45℃; under 760.051 Torr; for 48h; enantioselective reaction; | 82% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 8.5h; | 77.1% |
p-aminophenyl acetate
bis(pinacol)diborane
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl acetate
Conditions | Yield |
---|---|
With tert.-butylnitrite; dibenzoyl peroxide In acetonitrile at 20℃; for 2h; Sandmeyer reaction; | 73% |
With tert-butyl nitrite; benzoyl peroxide In acetonitrile MeCN, AcOC6H4NH2 (1 mmol) and tBuONO (1.5 mmol) added to B2pin2 (1 mmol)and benzoyl peroxide (0.02 mmol), mixt. stirred at room temp. for 2 h; soln. concd. (under reduced pressure), residue chromd.; | 73% |
4-formylphenyl acetate
p-aminophenyl acetate
tert-butylisonitrile
propionic acid
Conditions | Yield |
---|---|
In methanol at 20℃; for 5h; Ugi Condensation; Inert atmosphere; | 73% |
p-aminophenyl acetate
2-methyl-5-nitrobenzoyl chloride
2-methyl-5-nitro-N-(4-acetoxyphenyl)benzamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 5h; Ambient temperature; | 71% |
p-aminophenyl acetate
3-(2-chlorocarbonyl-ethyldisulfanyl)-propionyl chloride
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane | 69% |
Conditions | Yield |
---|---|
Stage #1: p-aminophenyl acetate; benzenediazonium tetrafluoroborate; acetonitrile With potassium carbonate at 90℃; for 2h; Green chemistry; Stage #2: With [bis(acetoxy)iodo]benzene at 25℃; for 2h; Green chemistry; chemoselective reaction; | 63% |
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In toluene at 120℃; for 48h; | 62% |
p-aminophenyl acetate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 5 - 25℃; for 2h; | 61.6% |
p-aminophenyl acetate
di-tert-butyl dicarbonate
Conditions | Yield |
---|---|
With bismuth (III) nitrate pentahydrate In neat (no solvent) at 40℃; for 0.166667h; | 61% |
p-aminophenyl acetate
4-Nitrophenacyl bromide
Conditions | Yield |
---|---|
With sodium carbonate In methanol for 12h; Ambient temperature; | 60% |
The Phenol, 4-amino-,1-acetate, with CAS registry number 13871-68-6, has the systematic name of 4-aminophenyl acetate. Besides this, it is also called 1-Acetoxy-4-aminobenzene. And the chemical formula of this chemical is C8H9NO2. When use this chemical, please do not breathe dust and avoid contact with skin and eyes. What's more, its EINECS is 214-828-7.
Physical properties of Phenol, 4-amino-,1-acetate: (1)ACD/LogP: -0.16; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.18; (4)ACD/LogD (pH 7.4): -0.16; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 18.83; (8)ACD/KOC (pH 7.4): 19.49; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 29.54 Å2; (13)Index of Refraction: 1.56; (14)Molar Refractivity: 41.82 cm3; (15)Molar Volume: 129.3 cm3; (16)Polarizability: 16.58×10-24cm3; (17)Surface Tension: 44.8 dyne/cm; (18)Density: 1.168 g/cm3; (19)Flash Point: 135.8 °C; (20)Enthalpy of Vaporization: 51.43 kJ/mol; (21)Boiling Point: 275.9 °C at 760 mmHg; (22)Vapour Pressure: 0.00497 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Oc1ccc(cc1)N)C
(2)InChI: InChI=1/C8H9NO2/c1-6(10)11-8-4-2-7(9)3-5-8/h2-5H,9H2,1H3
(3)InChIKey: QVJWBJWRAPJXNM-UHFFFAOYAI
(4)Std. InChI: InChI=1S/C8H9NO2/c1-6(10)11-8-4-2-7(9)3-5-8/h2-5H,9H2,1H3
(5)Std. InChIKey: QVJWBJWRAPJXNM-UHFFFAOYSA-N
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