Pyrazolo[1,5-a]pyridine-3-carboxylic acid

The Pyrazolo[1,5-a]pyridine-3-carboxylic acid, with CAS registry number 16205-46-2, has the systematic name of pyrazolo[1,5-a]pyridine-3-carboxylic acid. Besides this, it is also called H-pyrazolo[1,5-a]pyridine-3-carboxylic acid. And the chemical formula of this chemical is C₈H₆N₂O₂.

Physical properties of Pyrazolo[1,5-a]pyridine-3-carboxylic acid: (1)ACD/LogP: 1.35; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.67; (4)ACD/LogD (pH 7.4): -1.79; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 43.6 Å²; (13)Index of Refraction: 1.676; (14)Molar Refractivity: 43.02 cm³; (15)Molar Volume: 114.3 cm³; (16)Polarizability: 17.05×10^-24cm³; (17)Surface Tension: 60.5 dyne/cm.

Preparation: this chemical can be prepared by pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester. This reaction will need reagent 50% NaOH. The yield is about 93%.

Uses of Pyrazolo[1,5-a]pyridine-3-carboxylic acid: it can be used to produce pyrazolo[1,5-a]pyridine. This reaction will need reagent polyphosphoric acid. The reaction time is 16 hour(s) with reaction temperature of 80 ℃. The yield is about 89%.

When you are using this chemical, please be cautious about it as the following:
The Pyrazolo[1,5-a]pyridine-3-carboxylic acid irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)c1cnn2c1cccc2
(2)InChI: InChI=1/C8H6N2O2/c11-8(12)6-5-9-10-4-2-1-3-7(6)10/h1-5H,(H,11,12)
(3)InChIKey: HRSDPDBQVZHCRC-UHFFFAOYAD
(4)Std. InChI: InChI=1S/C8H6N2O2/c11-8(12)6-5-9-10-4-2-1-3-7(6)10/h1-5H,(H,11,12)
(5)Std. InChIKey: HRSDPDBQVZHCRC-UHFFFAOYSA-N