Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.
OSHA PEL: TWA 0.05 mg/m3 (skin); STEL 0.15 mg/m3 (skin)
ACGIH TLV: TWA 0.05 mg/m3 (skin)
DFG MAK: 0.05 mg/m3
DOT Classification: 6.1; Label: Poison
The Sodium fluoroacetate, with the CAS registry number 62-74-8,is also known as Monofluoressigsaures natrium . It belongs to the product categories of Organic matters. This chemical's molecular formula is C2H2FNaO2 and Its EINECS number is 200-548-2.What's more,Its systematic name is Sodium fluoroacetate .It is a fine,white,odorless,powdered solid, which is air & water reactions water soluble. It is used as a rodenticide. It is used as kill rat poison and toxic to humans and animals.And it can be derived from hydrolysis of fluoroacetamide with sodium hydroxide .
Physical properties about Sodium fluoroacetate are:
(1)ACD/LogP: -0.226; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.05; (4)ACD/LogD (pH 7.4): -3.94; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Flash Point: 55.3 °C; (13)Enthalpy of Vaporization: 44.59 kJ/mol; (14)Boiling Point: 167.9 °C at 760 mmHg; (15)Vapour Pressure: 0.828 mmHg at 25°C
You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].[O-]C(=O)CF;
(2)Std. InChI:InChI=1S/C2H3FO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1;
(3)Std. InChIKey:JGFYQVQAXANWJU-UHFFFAOYSA-M;
Safety Information of Sodium fluoroacetate:
The Sodium fluoroacetate is Very toxic to aquatic organisms. So avoid release to the environment. Refer to special instructions / safety data sheets. When you use it ,keep away from food, drink and animal foodstuffs,and do not breathe dust. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) .
The toxicity data of Sodium fluoroacetate as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | intraperitoneal | 102mg/kg (102mg/kg) | Australian Wildlife Research. Vol. 15, Pg. 239, 1988. | |
bird - wild | LD50 | oral | 2370ug/kg (2.37mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
bird - wild | LD50 | subcutaneous | 630ug/kg (.63mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ATAXIA | Australian Wildlife Research. Vol. 11, Pg. 373, 1984. |
cat | LD50 | intraperitoneal | 300ug/kg (.3mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
cat | LD50 | oral | 350ug/kg (.35mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 307, 1948. | |
chicken | LDLo | oral | 5900ug/kg (5.9mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 36, Pg. 59, 1947. | |
dog | LD50 | intravenous | 60ug/kg (.06mg/kg) | Yakkyoku. Pharmacy. Vol. 31, Pg. 1385, 1980. | |
dog | LD50 | oral | 66ug/kg (.066mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 82, 1951. | |
domestic animals - goat/sheep | LD50 | intramuscular | 700ug/kg (.7mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
domestic animals - goat/sheep | LD50 | intraperitoneal | 200ug/kg (.2mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
domestic animals - goat/sheep | LD50 | oral | 500ug/kg (.5mg/kg) | CARDIAC: OTHER CHANGES | Australian Wildlife Research. Vol. 9, Pg. 487, 1982. |
domestic animals - goat/sheep | LDLo | intravenous | 519ug/kg (.519mg/kg) | ENDOCRINE: HYPERGLYCEMIA MUSCULOSKELETAL: OTHER CHANGES LIVER: OTHER CHANGES | Journal of Comparative Pathology and Therapeutics. Vol. 70, Pg. 145, 1960. |
duck | LD50 | oral | 4810ug/kg (4.81mg/kg) | Toxicology and Applied Pharmacology. Vol. 22, Pg. 556, 1972. | |
frog | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
frog | LDLo | oral | 54mg/kg (54mg/kg) | Veterinary and Human Toxicology. Vol. 15, Pg. 6, 1973. | |
guinea pig | LD50 | intraperitoneal | 378ug/kg (.378mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 62, 1949. | |
guinea pig | LD50 | oral | 300ug/kg (.3mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
guinea pig | LD50 | skin | 1600ug/kg (1.6mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969. |
guinea pig | LD50 | subcutaneous | 250ug/kg (.25mg/kg) | Biochemical Pharmacology. Vol. 6, Pg. 169, 1961 | |
horse/donkey | LD50 | unreported | 1mg/kg (1mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
human | LDLo | oral | 714ug/kg (.714mg/kg) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 542, 1969. | |
mammal (species unspecified) | LD50 | intraperitoneal | 100ug/kg (.1mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 36, Pg. 59, 1947. |
mammal (species unspecified) | LD50 | oral | 110ug/kg (.11mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Australian Wildlife Research. Vol. 8, Pg. 385, 1981. |
man | LDLo | unreported | 5mg/kg (5mg/kg) | CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. |
monkey | LD50 | intravenous | 5mg/kg (5mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
monkey | LD50 | oral | 300mg/kg (300mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969. |
mouse | LD50 | intraperitoneal | 7mg/kg (7mg/kg) | Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 34, Pg. 193, 1979. | |
mouse | LD50 | oral | 100ug/kg (.1mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977. | |
mouse | LD50 | skin | 25300ug/kg (25.3mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969. |
mouse | LD50 | subcutaneous | 7200ug/kg (7.2mg/kg) | National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. 30101, Pg. 2, 1945. | |
mouse | LD50 | unreported | 10mg/kg (10mg/kg) | Yakkyoku. Pharmacy. Vol. 30, Pg. 397, 1979. | |
pig | LD50 | intraperitoneal | 300ug/kg (.3mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
pigeon | LD50 | oral | 2mg/kg (2mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 36, Pg. 59, 1947. | |
quail | LD50 | oral | 18mg/kg (18mg/kg) | Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971. | |
rabbit | LD50 | intravenous | 300ug/kg (.3mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
rabbit | LD50 | oral | 340ug/kg (.34mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Australian Wildlife Research. Vol. 9, Pg. 487, 1982. |
rabbit | LD50 | subcutaneous | 281ug/kg (.281mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 62, 1949. | |
rat | LD50 | intraperitoneal | 1940ug/kg (1.94mg/kg) | British Journal of Experimental Pathology. Vol. 50, Pg. 277, 1969. | |
rat | LD50 | oral | 100ug/kg (.1mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. | |
rat | LD50 | skin | 48mg/kg (48mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 182, 1969. | |
rat | LD50 | unreported | 15mg/kg (15mg/kg) | Yakkyoku. Pharmacy. Vol. 30, Pg. 397, 1979. | |
squirrel | LD50 | intraperitoneal | 400ug/kg (.4mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 36, Pg. 59, 1947. |
squirrel | LD50 | oral | 300ug/kg (.3mg/kg) | American Journal of Public Health and the Nation's Health. Vol. 36, Pg. 1427, 1946. |
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