Clodinafop-propargyl

Details:

APPLICATIONS
clodinafop-propargyl
Biochemistry Fatty acid synthesis inhibitor, by inhibition of acetyl CoA carboxylase (ACCase).  Mode of action Post-emergence, systemic grass herbicide. Phytotoxic symptoms appear within 1-3 weeks, affecting meristematic tissue.  Uses Used for post-emergence control of annual grasses, including Avena, Lolium, Setaria, Phalaris and Alopecurus, in cereals, at 30-60 g/ha. Phytotoxicity Low toxicity to spring and winter wheat.  Formulation types EC; WP.  Compatibility Mainly used in combination with the safener cloquintocet-mexyl.  Selected products: mixtures: 'Celio' (+ cloquintocet-mexyl) (France) (Syngenta); 'Topik' (+ cloquintocet-mexyl) (Syngenta)

OTHER PRODUCTS
clodinafop-propargyl
'Conduct' (Syngenta); 'Discover' (Syngenta); 'Magestan' (Syngenta); 'Boulevard' (GreenCrop); 'Marathon' (Me2) mixtures: 'Hawk' (+ trifluralin) (Syngenta); 'Horizon' (+ cloquintocet-mexyl) (Canada) (Syngenta); 'Amazon' (+ diflufenican) (Bayer CropScience, Syngenta); 'Lucifer' (+ diflufenican) (Bayer CropScience) Discontinued products mixtures: 'Amazon TP' * (+ diflufenican) (Novartis)

ANALYSIS
Details available from Syngenta. 

MAMMALIAN TOXICOLOGY
clodinafop-propargyl
Oral Acute oral LD50 for male rats 1392, female rats 2271, mice >2000 mg/kg.  Skin and eye Acute percutaneous LD50 for rats >2000 mg/kg. Non-irritating to eyes and skin (rabbits). May cause skin sensitisation (guinea pigs).  Inhalation LC50 (4 h) for rats 2.325 mg/l air.  NOEL (2 y) for rats 0.35, (18 mo) for mice 1.2, (1 y) for dogs 3.3 mg/kg b.w. daily.  ADI 0.004 mg/kg b.w.  Toxicity class WHO (a.i.) III (company classification)  EC classification (R22, R43) 

ECOTOXICOLOGY
clodinafop-propargyl
Birds LD50 (8 d) for mallard ducks >2000, bobwhite quail >1455 mg/kg.  Fish LC50 (96 h) for rainbow trout 0.39, carp 0.46, catfish 0.43 mg/l.  Daphnia LC50 (48 h) >74 mg/l.  Algae EC50 (96-120 h) for Scenedesmus subspicatus 25, Microcystis >65.5, Navicula 6.8 mg/l.  Bees LD50 (48 h, oral and contact) >100 mg/bee.  Worms LC50 for earthworms 210 mg/kg. 

ENVIRONMENTAL FATE
Animals Hydrolysed to the corresponding acid which is excreted in urine and faeces.  Plants In plants, rapidly degraded to the acid derivative as major metabolite.  Soil/Environment In soil, undergoes rapid degradation to the free acid (DT50 <2 h) and then further to phenyl and pyridine moieties which are bound to the soil and mineralised. The free acid is mobile in soil, but is further degraded with DT50 5-20 d; in practice, there is a negligible leaching potential.