Trimethylsulphoxonium Iodide

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0 Metric Ton	Negotiable

0 Metric Ton

Negotiable

Min.Order :0 Metric Ton
Purity: 98%

Keywords

TMSOI;NSC 71213;RARECHEM AQ A1 0066;Trimethylsulfoxonium;trimethyl-sulfoxoniuiodide;TRIMETHYLSULFOXONIUM IODIDE;trimethylsulphoxoniumioidie;Trimethylsulfoxonium iodate;Trimethysulfoxonium Iodide;TRIME

Quick Details

Appearance:
Application:Treatment with strong base yields the ylide which adds to the carbonyl group of ketones1 and aldehydes2,3 to give epoxides. Also adds preferentially to the double bond of α,β-unsaturated esters to g
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Superiority:

Trimethylsulfoxonium iodide is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride.The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.

Details:

TMSI (Trimethyl sulfoxonium iodide) is usually used as pharmaceutical intermediates. Trimethylsulfoxonium iodide is useful for preparing ylides in strong base condition. The Treatment with strong base (such as sodium hydride) yields the ylide which adds to the carbonyl group of ketones and aldehydes to generate the Corey-Chaykovsky reagent. Also cyclopropanation can be carried out in ionic liquids with high yields preferentially to the double bond of alpha,beta-unsaturated esters to give cyclopropyl esters.

Examples of end products from Trimethylsulphoxonium iodide are anti-fungal agents such as Fluconazole.

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