Citric acid monohydrate

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1 Gram	FOB Price: USD 1.0000

1 Gram

FOB Price: USD 1.0000

Min.Order :1 Gram
Purity: 99%
Payment Terms : L/C,T/T,Other

Keywords

Citric acid monohydrate 5949-29-1 99%

Quick Details

Appearance:as description
Application:for research
PackAge:10g, 100g,1kg
ProductionCapacity:1|Metric Ton|Day
Storage:Room tempurature
Transportation:by air

Superiority:

Shanghai, Run-Biotech Co., Ltd is a leading domestic pharmaceutical, biopharmaceutical, and health care products R & D outsourcing services company. As an innovation-driven and customer-focused company, Run Biotech provides a broad and integrated portfolio of services throughout the drug R&D process. Our services are designed to help our worldwide customers shorten the discovery and development time and lower the cost of drug and medical device R&D through cost-effective and efficient outsourcing solutions.

Based on our technical expertise and excellent research facilities, we successfully establish facilities, advanced R & D services technology platform. We will achieve leapfrog all-round development in the field of chemical synthesis, medicinal chemistry, biological and so on.

Run Biotech has further enhanced the integrated services with analytical services, bio-analytical services, process research, process development services, API manufacturing services, discovery biology, pharmacology, formulation services, biologics manufacturing services, antibody, biological research reagent manufacturing and sales services.

In Taiwan , Mainland China and Southeast Asia, Run Biotech has its own logistics center, provides the professional, personalized one-stop services, offers a variety of technologies and products and services for the world's major technology and industrial customers.

Details:

Citric acid monohydrate Basic information

Product Name:	Citric acid monohydrate
Synonyms:	CitronensαureMonohydrat;PROPANONE;PYROACETIC ETHER;FEMA 3326;EXTRAN AP 22;EXTRAN(R) AP 22;EXTRAN(R) AP22, ACID RINSE DETERGENT WITH CITRIC ACID;EXTRAN(R) AP22 DETERGENT
CAS:	5949-29-1
MF:	C6H10O8
MW:	210.1388
EINECS:	200-662-2
Product Categories:	-;C-D, Puriss p.a. ACS;Puriss p.a. ACS;Buffers A to ZCarbonyl Compounds;Other BiochemicalBiological Buffers;Biochemicals Found in Plants;C6Nutrition Research;Carboxylic Acids;SigmaUltra Buffers;ACS GradeCarbonyl Compounds;Essential Chemicals;Other Biochemical;Analytical Reagents;Analytical Reagents for General Use;Puriss;Buffers A to ZEssential Chemicals;USP/MultiCompendial Grade Buffers;USPBiological Buffers;Biological Buffers;Routine Reagents;Buffers A to ZNutrition Research;Reagent GradeMetabolic Pathways;Metabolites and Cofactors on the Metabolic Pathways Chart;Other BiochemicalEssential Chemicals;TCA;Food additive and acidulant;#N/A;BioXtra Buffers;Biological Buffers;Buffers A to Z;Building Blocks;C6;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Nutrition Research;Organic Building Blocks;Other Biochemical;Phytochemicals by Chemical Classification;ACS Grade;Essential Chemicals;Inorganic Salts;Research Essentials;Solutions and Reagents;Citric Acid Monohydrate is mainly used as acidulating, flavoring and preservative in foods and beverages
Mol File:	5949-29-1.mol

Citric acid monohydrate Chemical Properties

Melting point	-94 °C(lit.)
Boiling point	56 °C760 mm Hg(lit.)
density	0.791 g/mL at 25 °C(lit.)
vapor density	2 (vs air)
vapor pressure	184 mm Hg ( 20 °C)
refractive index	n20/D 1.359(lit.)
Fp	1 °F
storage temp.	Store at RT.
solubility	H2O: soluble54% (w/w) at 10°C (Citric acid in water)
form	Solid
color	White
Specific Gravity	0.810 (20/4℃)
PH	1.85 (50g/l, H2O, 25℃)
Water Solubility	1630 g/L (20 ºC)
Sensitive	Hygroscopic
Merck	14,2326
BRN	4018641
Stability:	Stable. Incompatible with oxidizing agents, bases, reducing agents, nitrates.
InChIKey	YASYEJJMZJALEJ-UHFFFAOYSA-N
CAS DataBase Reference	5949-29-1(CAS DataBase Reference)
NIST Chemistry Reference	Citric acid monohydrate(5949-29-1)

Safety Information

Hazard Codes	F,Xi
Risk Statements	11-36-66-67-41-36/37/38-37/38
Safety Statements	9-16-26-37/39-36/37/39-36
RIDADR	UN 1090 3/PG 2
WGK Germany	1
RTECS	AL3150000
TSCA	Yes
HS Code	29181400
Toxicity	LD50 orally in Rabbit: 3000 mg/kg

MSDS Information

Provider	Language
Citric acid monohydrate	English
SigmaAldrich	English
ALFA	English

Citric acid monohydrate Usage And Synthesis

Chemical Properties	white crystals or powder
Chemical Properties	Citric acid monohydrate occurs as colorless or translucent crystals, or as a white crystalline, efflorescent powder. It is odorless and has a strong acidic taste. The crystal structure is orthorhombic.
Production Methods	Citric acid occurs naturally in a number of plant species and may be extracted from lemon juice, which contains 5–8% citric acid, or pineapple waste. Anhydrous citric acid may also be produced industrially by mycological fermentation of crude sugar solutions such as molasses, using strains of Aspergillus niger . Citric acid is purified by recrystallization; the anhydrous form is obtained from a hot concentrated aqueous solution and the monohydrate from a cold concentrated aqueous solution.
Pharmaceutical Applications	Citric acid (as either the monohydrate or anhydrous material) is widely used in pharmaceutical formulations and food products, primarily to adjust the pH of solutions. It has also been used experimentally to adjust the pH of tablet matrices in enteric-coated formulations for colon-specific drug delivery. Citric acid monohydrate is used in the preparation of effervescent granules, while anhydrous citric acid is widely used in the preparation of effervescent tablets. Citric acid has also been shown to improve the stability of spray-dried insulin powder in inhalation formulations. In food products, citric acid is used as a flavor enhancer for its tart, acidic taste. Citric acid monohydrate is used as a sequestering agent and antioxidant synergist. It is also a component of anticoagulant citrate solutions. Therapeutically, preparations containing citric acid have been used to dissolve renal calculi.
Safety	Citric acid is found naturally in the body, mainly in the bones, and is commonly consumed as part of a normal diet. Orally ingested citric acid is absorbed and is generally regarded as a nontoxic material when used as an excipient. However, excessive or frequent consumption of citric acid has been associated with erosion of the teeth. Citric acid and citrates also enhance intestinal aluminum absorption in renal patients, which may lead to increased, harmful serum aluminum levels. It has therefore been suggested that patients with renal failure taking aluminum compounds to control phosphate absorption should not be prescribed citric acid or citrate-containing products.
storage	Citric acid monohydrate loses water of crystallization in dry air or when heated to about 408℃. It is slightly deliquescent in moist air. Dilute aqueous solutions of citric acid may ferment on standing.
Purification Methods	Crystallise it from hot H2O solution (w/w solubility is 54% at 10o, 71% at 50o and 84% at 100o. The monohydrate (softens at ~75o and melts at ~100o) dehydrates in air or when heated gently above 40o . The triethylester ( M 276.3, b 127o/1mm, 294o/atm, d 4 1.137, n D 1.4420.) is a bitter tasting oil. [Beilstein 3 H 556 and 568, 3 IV 1272.]
Incompatibilities	Citric acid is incompatible with potassium tartrate, alkali and alkaline earth carbonates and bicarbonates, acetates, and sulfides. Incompatibilities also include oxidizing agents, bases, reducing agents, and nitrates. It is potentially explosive in combination with metal nitrates. On storage, sucrose may crystallize from syrups in the presence of citric acid.
Regulatory Status	GRAS listed. The anhydrous form is accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; IM, IV, and other injections; ophthalmic preparations; oral capsules, solutions, suspensions and tablets; topical and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in Japan and the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Citric acid monohydrate Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Hydrochloric acid-->Sulfuric acid -->Calcium carbonate
Preparation Products	ribonucleic acid for injection-->2-(1H-PYRAZOL-1-YL)BENZOIC ACID-->3-(1H-PYRAZOL-3-YL)BENZOIC ACID-->ANGIOTENSIN II, HUMAN-->TERT-BUTYL (3S)-3-AMINOBUTANOATE-->LORACARBEF (200 MG)-->Ritonavir-->Prostaglandin E2 -->red kojic rice-->Calcium citrate-->Clomifene citrate-->citric acid, iron(3+) salt

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Citric acid monohydrate

CAS NO:5949-29-1