API
COS, DMF
Carbidopa is a drug given to patient with Parkinson's disease in order to inhibit peripheral metabolism of levodopa.
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Item |
Specifications |
Results |
Appearance |
White to creamy white powder |
Creamy white powder |
Solubility |
Meets the requirements |
Meets the requirements |
IR |
The spectrum of sample comlies with the spectrum obtained with standard |
Complies |
Assay: RT |
Corresponds to the peak obtained with the standard |
Corresponds |
Specific rotation |
-21°~-23.5° |
-22.2° |
Loss on drying |
6.9%-7.9% |
7.3% |
Residue on ignition |
Not more than 0.1% |
0.03% |
Heavy metals |
Not more than 0.001% |
Less than 0.001% |
Methyldopa |
Not more than 0.5% |
0.18% |
Carbidopa related compound A |
Not more than 0.5% |
0.08% |
Residual solvents |
Meets the requirements |
Meets the requirements |
Assay |
980-102.0% |
99.3% |
Conclusion |
Conforms to USP32 |
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