Cyromazine

Superiority:

Cyromazine is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects.

In veterinary medicine, cyromazine is used as an ectoparasiticide.

Cyromazine

Cyromazine is a triazine IGR with applications in sheep for the prevention of cutaneous myiasis and as a poultry feed-through agent for fly control in chicken feces.

Antiparasitic drugs

Stephen W Page, in Small Animal Clinical Pharmacology (Second Edition), 2008

Cyromazine

N-cyclopropyl-1,3,5-triazine-2,4,6-triamine.

Clinical applications

Cyromazine is a triazine IGR with applications in sheep for the prevention of cutaneous myiasis and as a poultry feed-through agent for fly control in chicken feces. Because of its novel and specific mode of action, the mammalian toxicity is of a very low order.

Cyromazine has been shown in in vitro bio-assays to inhibit larval and pupal development in Ctenocephalides canis by disrupting cuticle turnover during ecdysis. This effect is also observed in the offspring of fleas feeding on dogs administered cyromazine orally.

Pharmacokinetics

Cyromazine is rapidly absorbed following oral administration, with most of the dose excreted in urine within 3 d. At low doses, coadministration with food results in loss of efficacy. However, at higher doses this effect is less clinically relevant.

Adverse effects

Despite an apparently high margin of safety for cyromazine, when combined with DEC for daily administration, serious and life-threatening adverse effects have been encountered, although the mechanism of these effects is unclear.