Fostriecin

Product Name

Fostriecin

CAS No.

87860-39-7

Synonyms

Phosphotrienin; Fostriecin sodium salt; CI-920; CL-1565A; NSC-339638; Pyranone phosphate; (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one monosodium salt

Molecular Formula

C₁₉H₂₆O₉PNa

Molecular Weight

452.37

MDL

MFCD01939908

InChI

1/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1/b3-2-,6-4+,8-5-,12-11+;/t15-,16+,17+,19+;/m0./s1

Appearance

Solid

Purity

99 %

Boiling Point (760 mmHg)

737.9 °C

Flash Point

400.1 °C

WGK Germany 

3

RTECS

UQ0600000

Main Applications

Fostriecin is an antibiotic which has been shown to inhibit the catalytic activity of partially purified Topo II (type II topoisomerase) in a non-competitive manner. Unlike other known inhibitors of this enzyme, fosteriecin has not been observed to cause DNA strand breaks in L1210 cells, suggesting that it does not stabilize a cleavable complex. Fostriecin has also displayed a strong capacity to inhibit protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A).

Grade

Pharma Grade

Packaging

According to customer's request

Storage and Transportation

Storage in original sealed container. Recommended storage temperature: -20 °C. Protect from moisture, heat and foreign material.