Factory supply 99% ...

Factory supply 99% Granisetron hcl CAS 107007-99-8

Factory supply 99% Granisetron hcl CAS 107007-99-8

Min.Order / FOB Price:Get Latest Price

100 Gram

FOB Price: USD 10.0000

  • Min.Order :100 Gram
  • Purity: 97.0%~102.0%
  • Payment Terms : L/C,T/T,

Keywords

Granisetron hcl Granisetron 99% Granisetron hcl

Quick Details

  • Appearance:White powder
  • Application: Treatment of nausea and vomiting
  • PackAge:1kg/ctn, or as your requirement
  • ProductionCapacity:10|Metric Ton|Year
  • Storage:room temperature
  • Transportation:Regular transportation

Superiority:

Why is SINOWAY:

1) Specialized in pharmaceutical and healthcare industrial for 34 years.

2) ISO 9001:2015 & SGS audited supplier . 

3) Accept various payment terms : T.T 30-60 days.

4) We have warehouse in USA with quickly shipment .

5) We can do different terms of FOB ,CIF/CIP ,DDP ...

Details:

1. Company Profile:

SINOWAY INDUSTRIAL CO.,LTD is a state-owned company and a professional supplier in exporting 

Pharmaceutical Raw and its intermediates, Cosmetic Raw Material, Healthcare Product from China

since 1987, about 34 years experiences to Europe, America and Southeast Asia. We have  gained very 

good reputation from all our customers in the world.

Custom manuafacturing is very strong from us.We have developed some new items together with 

our local universityand institute special  for our oversea clients for long term business under signing secret 

agreement.

2. Quality information for Granisetron hcl

USP Current

Items Specifications Results
Appearance White or almost white powder Conforms
Identification                           
A: IR Spectrum A: Sample IR spectrum comparable with that of the standard Conforms
B: Chloride B: Positive Conforms
pH 4.0~6.5 5.92
Impurity E (by TLC) NMT0.5% <0.5%
Loss on drying NMT0.5% 0.03%
Heavy Metals NMT20ppm <20ppm
Related Compounds Impurity A: NMT1.0% ND
  Impurity B: NMT0.5% ND
  Impurity C: NMT0.2% 0.04%
  Impurity D: NMT0.1% ND
  Any other impurity : NMT1.0% 0.03%
  Total impurity: NMT1.0% 0.07%
Residual Solvents    
Ethanol NMT 1000ppm 314ppm
Isopropanol NMT 1000ppm 13ppm
DIchloromethane NMT 300ppm 2ppm
Assay by HPLC 97.0%~102.0% 100.10%
Conclusion The product meets USP Specifications

EP

Items Specifications Results
Appearance White or almost white powder Comlies
Solubility Freely soluble in water,sparingly soluble in methylene chloride,slightly soluble in Methanol. complies
Identification a) Infrared absorption spectrophtometry Comaprison: Granisetron Hydrochloride CRS                                                         b) It gives reaction (a) of chloride complies
a) Solution S Concordant with R.S    complies
b) Appearance of solution  Concordant with R.S complies
c) pH  4.0 to 6.5    4.6
d) Impurity E <0.5% complies
Related substance Total <1.0% 0.20%
  Impurity A ≤1.0% 0.02%
  Impurity B ≤0.5% 0.02%
  Impurity C ≤0.2% 0.02%
  Impurity D ≤0.1% 0.02%
  Any other impurity≤0.1% 0.02%
  Total ≤1.0% 0.01%
Heavy metal ≤10ppm <10ppm
Sulphated ash <0.1% 0.06%
Loss on drying <0.5% <0.1%
Residual Solvents methanol<0.3% 0.01%
Bacterialendotoxins <0.05EU/mg <0.05EU/mg
Assay 97%~102% 100.60%
Conclusion The results comply with the requirement of the EP7

3. Use for Granisetron hcl

1) Granisetron Hydrochloride is a highly s elective 5-HT 3 receptors inhibitor. It is favourable

effective for the prevention and the treatment of nausea and vomiting caused by actinotheraphy,

chemotherapy or surgical.

2) These factor cause intestine chromaffin cell to release of 5-HT which activation 5-HT 3 receptors

of nerve centre or vagus and hence resulting from reflection of vomit.

 

 

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