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Paclitaxel Paclitaxel powder 33069-62-4
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10. full experience in export
11. raw materials from chinese origin
Product Information
Product name |
Paclitaxel |
CAS No. |
33069-62-4 |
Molecular Formula |
C47H51NO14 |
Molecular Weight |
853.92 |
Quality Standard |
99% up, Medicine Grade |
Appearance |
White crystalline powder |
COA of Paclitaxel
ppearance |
White or almost white crystalline powder |
Identification |
FT-IR |
HPLC |
|
NMR |
|
Mass |
|
Solubility |
Soluble in ethanol, methanol, Chloroform, hardly soluble in water |
Specific Optical Rotation |
-49.0º ~ -55.0º at 20°C |
Melting Point |
213°C—216°C |
Water |
≤1.0% |
Residual Solvent |
Meets the requirements of ICH |
Ethyl Acetate |
≤5000ppm |
Acetone |
≤5000ppm |
Methanol |
≤3000ppm |
Acetic acid |
≤5000ppm |
Residual of volatile Solvents |
Meets the requirements of ICH |
Chloroform |
≤60ppm |
Dichloromethane |
≤600ppm |
Hexane |
≤290ppm |
Toluene |
≤890ppm |
Residue on Ignition |
≤0.2% |
Bacteria endotoxins |
≤0.4 USP EU/mg |
Total aerobic microbial count |
≤100 cfu/g |
Staphylococcus aureus |
Absence |
Pseudomonas aeruginosa |
Absence |
Salmonella species |
Absence |
Escherichia Coli |
Absence |
Heavy Metals |
≤20 ppm |
IMPURITIES: |
|
10-Deacetyl Baccatin III |
≤0.1% |
Baccatin III |
≤0.2% |
Photodegradant |
≤0.1% |
10-Deacetyl Paclitaxel |
≤0.5% |
2-Debenzoylpaclitaxel-2-pentenoate |
≤0.7% |
Oxetane ring opened, Acetyl and benzoyl |
≤0.1% |
10-Acetoacetyl paclitaxel |
≤0.1% |
10-Deacetyl-7-epi-paclitaxel |
≤0.3% |
|
≤0.4% |
7-epi-paclitaxel |
≤0.4% |
10,13-Bissidechainpaclitaxel |
≤0.5% |
7-Acetyl Paclitaxel |
≤0.6% |
Usage
Paclitaxel powder is a chemotherapy drug that is given as a treatment for some types of cancer. Paclitaxel powder is a mitotic inhibitor now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.
Function of Paclitaxel
1. Paclitaxel is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Paclitaxel has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
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