Letrozole 4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE FEMARA
Items |
Specification |
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Appearance |
White to yellowish, crystalline powder |
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Identification |
A.IR spectrum of sample should be identical to that of Reference Standard; |
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The retention time of major peak in the chromatogram of the Assay preparation should correspond to that in the chromatogram of Standard preparation, as obtained in the Assay. |
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Showing the white precipitate reaction. |
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Water |
Not more than 0.3% |
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Residue on Ignition |
Not more than 0.1% |
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Heavy Metals |
Not more than 0.001% |
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Related Compounds |
Compound A: Not more than 0.1% |
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4,4’,4”-methylidenetrisbenzonitrile: Not more than 0.2% |
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Any other impurity: Not more than 0.1% |
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All other impurities: Not more than 0.3% |
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Residual Sovents |
Ethanol: Not more than 3000ppm |
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Ethyl acetate: Not more than 2000ppm |
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DMF: Not more than 880ppm |
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Microbe Limit |
Bacteria: Not more than 200/g |
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Mold and yeast: Not more than 50/g |
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Escherichia coli: should be absent |
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Assay(anhydrous) |
98.0% to 102.0% of Cl7H11N5 on dried basis |
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Packaging and Storage |
Preserve in tight containers at controlled room temperature. |
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Conclusion |
Conforms to the USP32. |
1. Clobetasone butyrate (25122-57-0) is good for the treatment of congenital atopic dermatitis, face, neck, axilla, perineal eczema and other diseases.
2.Apply to affected area with ointment, 1, 1 ~ 3 times.
3. Clobetasone butyrate (25122-57-0) can cause local irritation, itching, acne, miliaria, white ringworm, etc. should be promptly disabled. 2. Large or long-term large-scale applications, there may be glucocorticoid side effects.
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