- Min.Order :1 Gram
- Purity: 99%+
- Payment Terms : T/T
Keywords
PF06463922 Lorlatinib (R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile
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- Appearance:
- Application:1454846-35-5 Pharmaceutical Intermediate
- PackAge:PE bag and AL bag, PE bottle
- ProductionCapacity:30|Kilogram|Month
- Storage:2-4℃
- Transportation:DHL or Fedex
Superiority:
Shanghai Hope-Chem Co.Ltd is a company that provides chemical reference standards and custom synthesis services to the pharmaceutical and related industries. Our focus in organic chemistry and years of experience in the field has enabled us to offer a varity of chemical compounds (API reference standards, metabolites, stable labeled isotopes, etc.) for a complete selection of available compounds.
Enough stock, much higher purity, competitive price and immediate shipment
Details:
Lorlatinib (PF-06463922) is a potent, dual ALK/ROS1 inhibitor, with Kis of 0.02 nM, 0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALK-L1196M, respectively.
Lorlatinib demonstrates significant cell activity against ALK and a large set of ALK clinical mutations with IC50 ranging from 0.2 nM-77 nM. Lorlatinib significantly inhibits cell proliferation and induces cell apoptosis in the HCC78 human NSCLC cells harboring SLC34A2-ROS1 fusions and the BaF3-CD74-ROS1 cells expressing human CD74-ROS1. Lorlatinib also shows potent growth inhibitory activity and induces apoptosis in the NSCLC cells harboring either non-mutant ALK or mutant ALK fusions
Non-Small Cell Lung Cancer (NSCLC)
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