AR-A014418

AR-A014418

AR-A014418

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1 Gram

Negotiable

  • Min.Order :1 Gram
  • Purity: 99%

Keywords

AR-A014418 487021-52-3 99% AR-A014418

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  • Application:487021-52-3
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  • ProductionCapacity:100g|Metric Ton|Day
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Details:

AR-A014418 inhibits GSK3 (IC50 = 104 +/- 27 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 microM) or 26 other kinases demonstrating high specificity for GSK3. Colon cancer HCT116 cells were sensitized to apoptosis by co-treatment with reovirus and a GSK-3beta inhibitor, AR-A014418 .

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