Resminostat

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1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 98%

Keywords

Resminostat(RAS2410; 4SC-201) 864814-88-0 98% Resminostat

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Application:864814-88-0
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ProductionCapacity:100g|Metric Ton|Day
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Resminostat strongly induced apoptosis (IC50=2.5-3 micromol/l in 3 out of 4 MM cell lines) in MM cell lines as well as primary MM cells. At 1micromol/l, resminostat inhibited proliferation and induced G0/G1 cell cycle arrest in 3 out of 4 MM cell lines accompanied with decreased levels of cyclin D1, cdc25a, Cdk4 and pRb as well as upregulation of p21. Resminostat decreased phosphorylation of 4E-BP1 and p70S6k indicating an interference with Akt pathway signalling. Treatment with resminostat resulted in increased protein levels of Bim and Bax and decreased levels of Bcl-xL. Caspases 3, 8 and 9 were activated by resminostat .

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