Acetamide,2-chloro-N-(2-nitrophenyl)-

Superiority:

The Acetamide,2-chloro-N-(2-nitrophenyl)-, with the CAS registry number 10147-70-3, is also known as N-Chloroacetyl-2-nitroaniline. This chemical's molecular formula is C₈H₇ClN₂O₃ and formula weight is 214.61. What's more, its IUPAC name is called 2-chloro-N-(2-nitrophenyl)acetamide.

Physical properties of Acetamide,2-chloro-N-(2-nitrophenyl)-: (1)ACD/LogP: 1.55; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.55; (4)ACD/LogD (pH 7.4): 1.55; (5)ACD/BCF (pH 5.5): 8.82; (6)ACD/BCF (pH 7.4): 8.82; (7)ACD/KOC (pH 5.5): 165.32; (8)ACD/KOC (pH 7.4): 165.31; (9)#H bond acceptors: 5; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.63; (13)Molar Refractivity: 51.91 cm³; (14)Molar Volume: 145.7 cm³; (15)Surface Tension: 59.5 dyne/cm; (16)Density: 1.472 g/cm³; (17)Flash Point: 207.5 °C; (18)Enthalpy of Vaporization: 67.33 kJ/mol; (19)Boiling Point: 419.5 °C at 760 mmHg; (20)Vapour Pressure: 3.01E-07 mmHg at 25°C.

Preparation: this chemical can be prepared by 2-nitro-aniline and chloroacetyl chloride. This reaction will need reagent glacial acetic acid. The reaction time is 1.5 hours with reaction temperature of 0 - 20 ℃. The yield is about 45%.

Uses of Acetamide,2-chloro-N-(2-nitrophenyl)-: it can be used to produce 2-benzoimidazol-1-yl-N-(2-nitro-phenyl)-acetamide by heating. This reaction will need solvent methanol with reaction time of 8 hours. The yield is about 68%.