Ethyl chlorofluoroacetate

Superiority:

The CAS register number of Acetic acid,2-chloro-2-fluoro-, ethyl ester is 401-56-9. It also can be called as Acetic acid, chlorofluoro-, ethyl ester and the systematic name about this chemical is ethyl 2-chloro-2-fluoroacetate. The molecular formula about this chemical is C₄H₆ClFO₂ and the molecular weight is 140.54. It belongs to the following product categories which include Fluorinated Building Blocks; Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds; Synthetic Organic Chemistry; C2 to C5; Carbonyl Compounds; Esters and so on.

Physical properties about Acetic acid,2-chloro-2-fluoro-, ethyl ester are: (1)ACD/LogP: 1.00; (2)ACD/LogD (pH 5.5): 1; (3)ACD/LogD (pH 7.4): 1; (4)ACD/BCF (pH 5.5): 3.4; (5)ACD/BCF (pH 7.4): 3.4; (6)ACD/KOC (pH 5.5): 83.63; (7)ACD/KOC (pH 7.4): 83.63; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 26.3Ų; (11)Index of Refraction: 1.39; (12)Molar Refractivity: 27.32 cm³; (13)Molar Volume: 115.2 cm³; (14)Polarizability: 10.83x10^-24cm³; (15)Surface Tension: 26.4 dyne/cm; (16)Enthalpy of Vaporization: 36.67 kJ/mol; (17)Boiling Point: 129 °C at 760 mmHg; (18)Vapour Pressure: 10.4 mmHg at 25°C.

Preparation: this chemical can be prepared by ethanol and chloro-fluoro-acetyl fluoride. The yield is about 47 %.

Uses of Acetic acid,2-chloro-2-fluoro-, ethyl ester: it can be used to produce chloro-fluoro-acetic acid at heating. This reaction will need reagent 1N aq. HCl. The yield is about 30%.