alpha-Phthalimidopropiophenone

Superiority:

his chemical is called alpha-Phthalimidopropiophenone, and its systematic name is 2-(1-oxo-1-phenylpropan-2-yl)-1H-isoindole-1,3(2H)-dione. With the molecular formula of C₁₇H₁₃NO₃, its molecular weight is 279.29. The CAS registry number of this chemical is 19437-20-8.

Other characteristics of the alpha-Phthalimidopropiophenone can be summarised as followings: (1)ACD/LogP: 3.38; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.38; (4)ACD/LogD (pH 7.4): 3.38; (5)ACD/BCF (pH 5.5): 218.7; (6)ACD/BCF (pH 7.4): 218.7; (7)ACD/KOC (pH 5.5): 1646.16; (8)ACD/KOC (pH 7.4): 1646.16; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 54.45 Å²; (13)Index of Refraction: 1.633; (14)Molar Refractivity: 76.47 cm³; (15)Molar Volume: 214.1 cm³; (16)Polarizability: 30.31×10^-24cm³; (17)Surface Tension: 56.2 dyne/cm; (18)Density: 1.304 g/cm³; (19)Flash Point: 204.4 °C; (20)Enthalpy of Vaporization: 70.55 kJ/mol; (21)Boiling Point: 447.2 °C at 760 mmHg; (22)Vapour Pressure: 3.43E-08 mmHg at 25°C.

Production method of this chemical: The alpha-Phthalimidopropiophenone could be obtained the reactants of 2-bromo-1-phenyl-propan-1-one and phthalimide; potassium salt, the solvent of ethanol. The yield is 60 %. In addition, this reaction should be taken for 5 hours with the heating. 

Uses of this chemical: The alpha-Phthalimidopropiophenone could react with trimethyl-silanecarbonitrile, and obtain the 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-trimethylsilanyloxy-butyronitrile. This reaction needs the reagents of KCN, 18-crown-6, and the solvent of CH₂Cl₂. The yield is 88 %. In additon, this reaction should be taken for 1.5 hours.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin, so you should wear suitable protective clothing when you use it. In case of contacting with