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Methopterin Mtx Methotrexatum
Basic informtion
Product Name: Methotrexate
Synonyms: Methotrexate; Methylaminopterin; Methylaminopterine;antifolan;L-(+)-Amethopterin; 4-Amino-N 10-methylpteroyl-L-glutamic acid; 4-Amino-10-methylpteroyl-L-glutamic acid ;(+)-4-Amino-10-Methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid
CAS NO: 59-05-2
Molecular formula: C20H22N8O5
Molecular weight: 454.44
Appearance: Yellow or Orange crystal powder
Assay: 98%-102%
Usage: Used as a antineoplastic and antirheumatic. A folic Acid antagonist
Items |
Specifications |
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Characters |
Yellow or orange crystalline, hygroscopic powder |
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Identification(IR) |
The IR spectrum of sample exhibits maxima only at the same wavelength as that a similar preparation of methotrexate CRS. |
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Solubility: |
Practically insoluble in water,I n ethanol[96 per cent] and in methylene chloride. It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides and carbonates. |
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Related Substances |
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Impurity B |
NMT0.3% |
|
Impurity C |
NMT0.5% |
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Impurity E |
NMT0.3% |
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Impurity H |
NMT0.2% |
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Impurity I |
NMT0.2% |
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Unspecified impurities |
NMT0.05% |
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Sum of impurities other than B,C&E |
NMT0.5% |
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Enantiomeric purity |
NMT3.0% |
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Heavy metals |
NMT 20PPM |
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Water |
NMT 13.0% |
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Sulphated Ash |
NOT MORE THAN 0.1% |
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Residual solvents |
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Ethyl ether |
NMT 500PPM |
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Acetone |
NMT 1000PPM |
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Ethanol |
NMT 2000PPM |
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Assay(on the anhydrous basis) |
98.0%~102.0% |
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Bacterial Endotoxin |
NMT 0.1EU/MG |
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Conclusion |
The product conforms to EP7.5 requirements. |
Packaging & Delivery
Packaging Details: 1kg/bag;5kg/tin or 25kg/drum
Delivery Detail: in 10 days after final confirmation
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