CAS 107868-30-4 6-Methyleneandrosta-1,4-diene-3,17-dione

 

1.Product Name: Exemestane, 6-Methyleneandrosta-1,4-diene-3,17-dione

2.Other Names: Aromasin

3.Type: Auxiliaries and Other Medicine Chemicals

4.Specification: 99%

5.Formula: C20H24O2

6.Mol Wt.: 296.41

7.CAS No.: 107868-30-4

8.EINECS No: 634-821-0

9.Appearance: White crystalline powder

 

Introduction

Exemestane (trade name Aromasin) is a drug used to treat breast cancer. It is a member of the class of drugs known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive,hormonally-responsive, hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers.

Function

1. Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.

2. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrateandrostenedione.

3. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." 4. By being structurally similar to enzyme targets, Exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.

 

Test  Item	Analysis  Specification	Result
Description	White crystalline power	white crystalline power
Identification	IR RT(HPLC)	Conforms
Residue on ignition	≤0.1%	0.05%
Heavy metals	≤10 ppm	Conforms
Water	≤0.5%	0.05%
Specific Optical Rotation	+290°~+300°	+296.96°
Impurity
Spirooxiran1	≤0.15%	Not Detected
Spirooxiran2	≤0.15%	Not Detected
Exemestane related compound A	≤0.15%	Not Detected
Any unspecified impurity	≤0.10%	0.04%
Total impurity	≤0.50%	0.21%
Assay(HPLC)	98.0~102.0%	101.97%
Micron		100%≤20um
Conclusion	Conform  to  USP  Standard