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Pimobendan 4 5-Dihydro-6-[2- (4-methoxyphenyl) -1h-Benzimidaz 17-Dihydroxy-4
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2. Quality control, GC&HPLC&NMR Test.
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Description:
Abstract:
CAS RN.: 74150-27-9
Molecular Weight: 334.3718
Molecular Formula: C19H18N4O2
Density: 1.36g/cm3
Pimobendan , its cas register number is 74150-27-9. It also can be called Pimobendane ; dl-Pimobendan ; and 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone . It is a positive inotrope, and sensitizes and increases the binding efficiency of cardiac myofibril to the calcium ions that are already present without increasing the consumption of oxygen and energy. It is metabolized into its active form by the liver, and is absorbed rapidly when given via the oral route and has a bioavailability of 60-65%.
Specifications:
Item |
Specifications |
Results |
Appearance |
White or slightly yellowish Powder |
Slightly yellowish |
solubility |
Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in methanol. |
Conforms |
Identification |
Infrared absorption spectrophotometry , Comparison pimobendan CRS |
Conforms |
Heavy metals |
≤10ppm |
1ppm |
Water |
≤1.0% |
0. 1% |
Assay (HPLC) |
98.0%~100.0% |
99.83% |
Sulphated ash |
≤0.1% |
0.01% |
Related substances(HPLC) |
Impurity A:≤0.1% |
0.03% |
Impurity B:≤0.1% |
0.07% |
|
Any other impurity:≤0.1% |
0.05% |
|
Total impurity:≤0.2% |
0.17% |
|
Conclusion |
The results conforms with Enterprise standards |
Uses:
Pimobendan (CAS NO.74150-27-9) has strong positive inotropic effect and a strong vasodilator and platelet aggregation, and is used for the treatment of chronic and acute heart failure. It is used in the management of heart failure in dogs, most commonly caused by myxomatous mitral valve disease (also known as endocardiosis), or dilated cardiomyopathy.
Packaging & Shipping:
Package: Double plastic bag inside, aluminum foil bag or fiber drum outside.
Delivery Detail: Within one week
Storage: Stored in a clean, cool, dry area; keep away from strong, direct light.
Shelf Life: Two years when properly stored.
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