How Dapoxetine hydrochloride Works
Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.
Common Effects of Dapoxetine hydrochloride.
The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia.
Discontinuation due to adverse effects is dose related. According to McMahon in recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo, dapoxetine 30 mg, and dapoxetine 60 mg respectively. Unlike others SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction, dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects on loss of libido (<1%) and ED (<4%).
Dapoxetine hydrochloride May Cause Adverse Effects.
As with any drug, dapoxetine hydrochloride may cause adverse effects. The most common of these include dizziness, nausea, headache and diarrhea. If any untoward or serious effects are experienced, they should be discussed with the prescribing medical practitioner.
Dapoxetine hydrochloride may interact with other drugs. This is important with drugs that may bring about similar adverse effects, such as those causing hypotension, or lowered blood pressure, especially on standing up. Concomitant diseases, such as liver or renal dysfunction and some cardiac diseases, may be a contraindication to using the drug, and the prescribing doctor should be informed of other medications or conditions.
The drug should not be taken as a chronic medication or as a daily dose. It should only be taken when needed. Dapoxetine hydrochloride should be taken before sexual intercourse is desired and not more than once in a 24 hour period.