- Min.Order :1 Gram
- Purity: 98%
- Payment Terms : L/C,D/A
Keywords
17395-31-2 64924-67-0 Halofuginone Hydrobromide
Quick Details
- Appearance: Off-white to white solid
- Application:Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa feb
- PackAge:Per request
- ProductionCapacity:1|Kiloliter|Day
- Storage:Under room temperature
- Transportation:By Sea, Air, Express
Superiority:
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Details:
Identification
CAS Number
17395-31-2
64924-67-0
Molecular Structure
structure of Halofuginone Hydrobromide CAS 17395-31-2
Name
Halofuginone Hydrobromide
Synonyms
(±)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide
(±)-trans-7-Bromo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone hydrobromide
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(±)-
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-, hydrobromide (1:1)
7-Brom-6-chlor-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-chinazolinonhydrobromid (1:1)
7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone hydrobromide (1:1)
7-Bromo-6-chloro-3-[3-(3-hydroxy-2-pipéridinyl)-2-oxopropyl]-4(3H)-quinazolinone, bromhydrate (1:1)
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)acetonyl)-, monohydrobromide
7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-2-oxopropyl)quinazolin-4(3H)-one monohydrobromide
7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]quinazolin-4(3H)-one monohydrobromide
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;hydrobromide
17395-31-2
64924-67-0
55837-20-2(halofuginone)
1217623-74-9(Halofuginone hydrochloride)
SMILES
c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)CC3C(CCCN3)O.Br
StdInChI
InChI=1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H
StdInChIKey
SJUWEPZBTXEUMU-UHFFFAOYSA-N
Molecular Formula
C16H18Br2ClN3O3
Molecular Weight
495.60
EINECS
241-422-7
Properties
Appearance
Off-white to white solid
Safety Data
WGK Germany
3
Specifications and Other Information of Our Halofuginone Hydrobromide CAS 17395-31-2
Standard
Enterprise standard
Identification Methods
HNMR, HPLC
Purity
98% min
Storage
Under the room temperature and away from light
Productivity
Hundreds of kilograms per month
Application
Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.
Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.Halofuginone therefore has potential for the treatment of autoimmune disorders.
Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.
General View of Documents
Halofuginone Hydrobromide CAS 17395-31-2 HNMR
Halofuginone Hydrobromide CAS 17395-31-2 HPLC
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