- Min.Order :1 Gram
- Purity: 98%
- Payment Terms : L/C,T/T
Keywords
82186-71-8 Halofuginon Lactate Halofuginon
Quick Details
- Appearance:Off-white to white solid
- Application:Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa feb
- PackAge:Per request
- ProductionCapacity:1|Metric Ton|Year
- Storage:Under room temperature
- Transportation:By express/air/sea
Superiority:
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Details:
Identification
CAS Number
82186-71-8
Name
Halofuginon Lactate
Synonyms
2-Hydroxypropanoic acid – 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone (1:1) [ACD/IUPAC Name]
2-Hydroxypropansäure –7-brom-6-chlor-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-chinazolinon (1:1) [German] [ACD/IUPAC Name]
Acide 2-hydroxypropanoïque – 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-pipéridinyl]-2-oxopropyl}-4(3H)-quinazolinone (1:1) [French] [ACD/IUPAC Name]
Propanoic acid, 2-hydroxy-, compd. with 7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone (1:1) [ACD/Index Name]
2-Hydroxypropanoic acid [ACD/IUPAC Name]
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one;2-hydroxypropanoic acid
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one and 2-hydroxypropanoic acid
82186-71-8 [RN]
Halofuginone lactate
Halofuginone lactate 100 g/mL in Acetonitrile
Halofuginone lactate 100 µg/mL in Acetonitrile – short expiry, for immediate use only
Molecular Structure
Structure of Halofuginon Lactate CAS 82186-71-8
SMILES
CC(C(=O)O)O.c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)C[C@H]3[C@@H](CCCN3)O
StdInChI
InChI=1S/C16H17BrClN3O3.C3H6O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;1-2(4)3(5)6/h5-6,8,14-15,19,23H,1-4,7H2;2,4H,1H3,(H,5,6)/t14-,15+;/m0./s1
StdInChIKey
GATQERNJKZPJNX-LDXVYITESA-N
Molecular Formula
C19H23BrClN3O6
Molecular Weight
504.76
Properties
Appearance
Off-white to white solid
Safety Data
WGK Germany
3
Specifications and Other Information of Our Halofuginon Lactate CAS 82186-71-8
Standard
Enterprise standard
Identification Methods
HPLC/HNMR
Purity
98%min
Package
According to customer requirements to packaging
Storage
Under the room temperature and away from light
Application
Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.
Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.Halofuginone therefore has potential for the treatment of autoimmune disorders.
Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.
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