Tigecycline 98% sup...

Tigecycline 98% supplier in China

Tigecycline 98% supplier in China

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  • Min.Order :0 Metric Ton
  • Purity: 98%
  • Payment Terms : L/C,T/T

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Tigecycline supplier Tigecycline China Tigecycline 98%

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  • Appearance:powder
  • Application:API
  • PackAge:7.5KG
  • ProductionCapacity:|Metric Ton|Day
  • Storage:Room temperature
  • Transportation:by air or by sea

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1. Introduction of Tigecycline

 

Product Name: Tigecycline
Cas Number: 220620-09-7

 

Tigecycline  is a glycylcycline antibiotic, its synonyms are 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-((((1,1-dimethylethyl)amino)acetyl)amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)- ; Tygacil ; (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide. The IUPAC name of  Tigecycline is N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(tert-butylamino)acetamide
The formula is C29H39N5O8 and the molecular weight is 585.65.

2. Basic Information of Tigecycline

 

Tigecycline(220620-09-7) is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. 

 

1) Properties of Tigecycline(220620-09-7)

Classification Code: Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial [bacterial protein synthesis inhibitor]
Product Categories: Antibacterial
XLogP3: -0.2
H-Bond Donor: 7
H-Bond Acceptor: 12
Surface Tension: 80.036 dyne/cm
Density: 1.455 g/cm3
Flash Point: 492.612 °C
Enthalpy of Vaporization: 135.666 kJ/mol
Boiling Point: 890.922 °C at 760 mmHg
Vapour Pressure of Tigecycline (CAS NO.220620-09-7): 0 mmHg at 25 °C


2) Uses of Tigecycline

Tigecycline (CAS NO.220620-09-7) is active against many bacteria including Gram-positive bacteria, Gram-negative bacteria and anaerobes ,it also has activity against methicillin-resistant Staphylococcus aureus (MRSA) and multi-drug resistant strains of acinetobacter baumannii. It may have no activity against Pseudomonas spp. or Proteus spp. The drug is licenced for the treatment of skin,soft tissue infections ,and intra-abdominal infections.

 

3) Mechanism of action

Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation.


4) Side effects of tigecycline
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. If you serious side effects of diarrhea, severe headache, pain behind your eyes, severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart...you'd better stop using tigecycline.
 

5) Dosing

Tigecycline is given by slow intravenous infusion (30 to 60 minutes). A single dose of 100 mg is given first, followed by 50 mg every twelve hours after that. Patients with impaired liver function need to be given a lower dose. No adjustment is needed for patients with impaired kidney function. It is not licensed for use in children.

 

6) Market Analysis for tigecycline

Clinical research data show that Tigecycline has a broad spectrum of antimicrobial effect, and it is effective to bacteria, for example, methicillin resistance of staphylococcus aureus. According to another research data shows, tigecycline has good curative for pathogenic. So tigecycline will be become the super antibiotics.

The price of tigecycline is 90.46 $/daily dose,  because the abuse siutation of antibiotics in China, the resistance of bacteria is growing, and the price of similar import drug is rising up. So the request of antibacterial is large in the market. What's more, the antimicrobial spectrum of tigecycline is wide , has ledd effect side. therefore, it will have enormous potential in the market.

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