4-Fluorobenzeneboronic acid

Details:

1. Introduction of 4-Fluorobenzeneboronic acid

4-Fluorobenzeneboronic acid (CAS NO.1765-93-1) is a similar white crystal and commonly used in coupled reaction. We can provide the ≥98%(HPLC) 4-Fluorobenzeneboronic acid and produce it 10 metric ton per year. Besides, we can send it from the beijing port.

Others:

Appearance: Similar white crystal
Assay: ≥98%(HPLC)
Formula:    C₆H₆BFO₂ 
M.W.:      139.92
Feature:  Similar white powder,   mp 260-265°C

Packaging: 25KG/NET Fiber Drum with double lined plastic bag inside

   

2. Basic information of 4-Fluorobenzeneboronic acid

1) Properties:

(1)H-Bond Donor: 2; (2)H-Bond Acceptor: 3; (3)Rotatable Bond Count: 1; (4)Exact Mass: 140.044488; (5)MonoIsotopic Mass: 140.044488; (6)Topological Polar Surface Area: 40.5; (7)Heavy Atom Count: 10; (8)Complexity: 102; (9)Covalently-Bonded Unit Count: 1.

2) Descriptors of Structure

InChI: InChI=1S/C6H6BFO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H
InChIKey: LBUNNMJLXWQQBY-UHFFFAOYSA-N
Canonical SMILES: B(C1=CC=C(C=C1)F)(O)O
IUPAC Name: (4-fluorophenyl)boronic acid

3) Safety Information

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
F: 10-21
Hazard Note: Irritant
HazardClass: IRRITANT

4) Application



4-Methoxy-4'-Fluordiphenylmethanol can be manufactured from the 4-Fluorobenzeneboronic acid (CAS NO.1765-93-1) at the temperature of 25 - 28 °C. This reaction which is a kind of Arylation needs reagent Rh(acac)(cyclooctene)₂, tri(tert-butyl)phosphine and solvent 1,2-dimethoxy-ethane, H₂O with reaction time of 16 hours. The yield of it is about 68%.