TMP-195

TMP-195

TMP-195

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0 Metric Ton

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  • Min.Order :0 Metric Ton
  • Purity: More than 98%
  • Payment Terms : L/C,T/T,

Keywords

TMP-195 TMP195 N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

Quick Details

  • Appearance:
  • Application: Use as research only
  • PackAge:1g,5g,10g,100g,1000g,
  • ProductionCapacity:|Metric Ton|Day
  • Storage:Store at -20°C
  • Transportation:by sea or by air

Superiority:

TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC50 of 300 nM

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Kailiqi Biopharma develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED materials & OLED intermediates and other fine chemicals.

Kailiqi Biopharma also wants to be the STRATEGIC PARTNER for more and more pharma and chemical companies with our below Superiority: 
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Details:

TMP195 blocks the accumulation of CCL2 protein in the supernatants of monocyte-derived macrophage differentiation cultures. TMP195 significantly increases the amount of CCL1 protein secreted by the monocytes compared to vehicle group. In the transcriptional profiling data from the PHA-stimulated PBMC experiments, CCL2 and CCL1 are respectively down- or upregulated by TMP195[1]. TMP195 occupies the acetyllysine-binding site of class IIa HDACs. TMP195 competes against binding of HDAC7 to a variety of side-chain modifications on the same peptide backbone, despite no interference with the activity of other acetyllysine reader proteins BRD4 (IC50>50 μM)[2].

[1]. Lobera M, et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25.

[2]. Guerriero JL, et al. Class IIa HDAC inhibition reduces breast tumors and metastases through anti-tumor macrophages. Nature. 2017 Mar 16;543(7645):428-432.


Kailiqi Biopharma is a professional manufacturer specialized in the production and distribution of active pharmaceutical ingredients and intermediates.. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED materials & OLED intermediates and other fine chemicals. Kailiqi Biopharma consists a team of professional analytical department complete QC&QA under strict SOPs, experienced sale and after-sale service, efficient logistic support. 
We are good at technology：
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4. Small molecule biologics (e.g. non-natural amino acids, fluorinated amino acids) 
5. Green reactions (ionic liquids/fluorous chemistry)

We could give you: 
1. Best quality in your requirement 
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