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Lysergicacid2-butylamide(2-Butyllysergamide,LSB)isananalogueoriginallydevelopedbyRichardPiochatElyLilliinthe1950s,butmostlypub…
Lysergic acid 2-butyl amide (2-Butyllysergamide, LSB) is an analogue originally developed by Richard Pioch at Ely Lilli in the 1950s, but mostly publicised through research conducted by the team led by David E. Nichols at Purdue University It is a structural isomer with the two ethyl groups on the amide nitrogen having been replaced by a single butyl group, joined at the 2-position.It i s one of the few lysegamide derivatives to exceed the potency in animal drug discrimination assays, with the (R) isomer having an ED50 of 33nmol/kg for producing drug-appropriate responding, vs 48nmol/kg. The corresponding (R)-2-pentyl analogue has higheraffinity for the 5-HT1A and 5-HT2A receptors, but is less potent in producing drug-appropriate responding, suggesting that the butyl compound has a higher efficacy at the receptor target.
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