Factory direct supply API Adenosine CAS:58-61-7

Min.Order / FOB Price:Get Latest Price

1 Metric Ton	FOB Price: USD 1.0000

1 Metric Ton

FOB Price: USD 1.0000

Min.Order :1 Metric Ton
Purity: 99
Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

58-61-7 API Adenosine

Quick Details

Appearance:White crystal powder
Application:Anti-arrhythmic drugs can convert paroxysmal supraventricular tachycardia to sinus rhythm. For room-related supraventricular arrhythmias.
PackAge:25 kg per barrel
ProductionCapacity:100|Metric Ton|Month
Storage:Warehouse ventilation and low temperature drying
Transportation:AS PER MSDS

Superiority:

Zhengzhou Yuanli Biological Technology Co., Ltd. (Primary Zhengzhou Sigma Chemical Co., LTD.) founded in 2009, is an intergrated enterprise which integrates R&D, achievement transformation, production, sales and import-export trade. It subordinates a subsidiarycompany: Zhengzhou Chemical Chem Co., Ltd，a production base: Suicheng Pharmaceutical Co., Ltd., and an European Sales Company (Covering European and Russian Markets): GloBS Chemical Ltd.. There are more than 100 employees and more than 85% are professionals.

The company is a scientific and technological enterprise. The core is R&D and the lifelong mission is development, transformation and application of new technologies.

So far, more than 20 pieces of products has been researched and developed and transformed to production successfully. All of them are exclusive worldwide. Such as acridine series and borane series, Zhengzhou Sigma is the company with the most advanced technology and ability of batch production and supply with largest quantity all over the world. We offer products and technical services to 36 countries.

"Professional, dedicated, making every effort" is the type of Sigma people. We are willing to provide you with the most professional consulting, design the products of your most need, control products to meet the best quality. Looking forward to cooperation and creating the brilliancy together.

Details:

Adenosine is an active substance based on nucleosides and purines. It is a nucleoside formed by the binding of adenine to β-glycosidic bonds to D-ribose. It is widely present in all types of cells. However, it may also be a compounded nucleoside. Adenosine phosphates such as ATP are important energy carriers in biochemical reactions.

Adenosine is a natural nucleotide that is an intermediate product of metabolism and one of the important active ingredients in the body. Its action is achieved by activating adenosine receptors (A receptors). In the atria, sinus node, and atrioventricular node, adenosine activates G protein-coupled potassium channels by binding to A receptors, increasing K+ efflux, and hyperpolarizing cell membranes, reducing autoregulation. It can also significantly increase the level of cGMP, prolong the atrioventricular node ERP and slow down the conduction, inhibit sympathetic or isoproterenol induced early and late depolarization and exert antiarrhythmic effect. This product is not yet classified in class I-IV antiarrhythmic drugs.

Adenosine is an inhibitory neuromodulator of the central nervous system that provides a signal between the brain's energy storage and energy needs to reach a balance. Under normal conditions, the concentration of extracellular adenosine is maintained at 40 to 400 nmol. When ischemic and hypoxic, both glucose and glycogen are rapidly decomposed to produce ATP to meet the energy requirements, and ATP is subsequently degraded, causing the intracellular adenosine levels to rise sharply and release into the cells to exert its regulatory effects. During the period of hypoxia recovery, endogenous adenosine is the precursor of ATP synthesis, and ATP can be generated under the catalysis of adenosine kinase (AK) to prolong cell survival time.

Adenosine has the effect of expanding coronary vessels and reducing myocardial contractility. Clinically suitable for the treatment of angina, hypertension, cerebrovascular disorders, stroke sequelae, progressive muscular dystrophy. Intravenous injection is used to treat supraventricular tachycardia and 201Tl myocardial imaging.

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