high purity Tenofov...

high purity Tenofovir disoproxil fumarate 98%min /White Solid
high purity Tenofovir disoproxil fumarate 98%min /White Solid

high purity Tenofovir disoproxil fumarate 98%min /White Solid

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10 Gram

Negotiable

  • Min.Order :10 Gram
  • Purity: ≥98%
  • Payment Terms : L/C,D/P,T/T,Other

Keywords

high purity Tenofovir disoproxil fumarate Tenofovir disoproxil fumarate White Solid Tenofovir disoproxil fumarate 98%min

Quick Details

  • Appearance:White powder
  • Application:Tenofovir;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
  • PackAge:100g/bag,500g/bag or bottle,1kg/bag or bottle,25kg/drum or packedon the clients' requirements
  • ProductionCapacity:1000|Kilogram|Month
  • Storage:Store in cool & dry place.Keep away from strong light and heat.
  • Transportation:air or ocean or rail or parcel post

Superiority:

We have high purity of Tenofovir disoproxil fumarate ,the purity is 98%min and it is White Solid.

Product Description
 
Tenofovir disoproxil fumarate Usage And Synthesis
Overview Tenofovir disoproxil fumarate, a prodrug of tenofovir[Trade name: “Viread”] developed by Gilead Sciences, is a kind of nucleotide-analogues antiretroviral drugs, taking effect through acting as the reverse transcriptase inhibitors[nRTIs], which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people[1-4]. It should be noted that it is the first nucleotide reverse transcriptase inhibitor that has ever used for the treatment of HIV infection[5]. Tenofovir disoproxil fumarate is converted to tenofovir in vivo, which is an acyclic nucleoside phosphonate[nucleotide] analog of adenosine 5'-monophosphate[5,6]. It is generally used in combination with other kinds of medicine. HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines[called an HIV regimen] every day can help people with HIV live longer, healthier lives[7]. Based on the FDA document, tenofovir disoproxil fumarate can also be for the treatment of chronic hepatitis B virus[HBV] infection in adults and children 12 years of age and older[1,3, 4, 8].
Indication and application Tenofovir disoproxil fumarate[trade name: Viread®], an antiviral drug, is indicated as the treatment for both HIV and Hepatitis B virus[HBV]. Viread® is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older[2,9].
Mode of action Tenofovir[the prodrug type of Viread] can effectively inhibit the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5'-triphosphate and, after incorporation into DNA, leading to DNA chain termination[1, 5, 7, 8]. Specifically, the drugs are analogues of the naturally occurring deoxynucleotides needed to synthesize the viral DNA and they compete with the natural deoxynucleotides for incorporation into the growing viral DNA chain[8, 10, 11]. However, unlike the natural deoxynucleotides substrates, NRTIs and NTRTIs[nucleoside/tide reverse transcriptase inhibitors] lack a 3'-hydroxyl group on the deoxyribose moiety. As a result, following incorporation of an NRTI or an NtRTI, the next incoming deoxynucleotide cannot form the next 5'-3' phosphodiester bond needed to extend the DNA chain. Thus, when an NRTI or NtRTI is incorporated, viral DNA synthesis is halted, a process known as chain termination. All NRTIs and NtRTIs are classified as competitive substrate inhibitors[2].
SUNSANTA
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Details:

We have high purity of Tenofovir disoproxil fumarate ,the purity is 98%min and it is White Solid.

Basic Information
Product Name Tenofovir disoproxil fumarate
Appearance White powder
Odor &Taste Characteristic
Test Method HPLC
Specification 98% min
Supplier  SUNSANTA
CAS# C19H30N5O10P.C4H4O4
Molecular Formula 202138-50-9
Molecular Weight  635.51
Structure high purity Tenofovir disoproxil fumarate 98%min /White Solid
Packing

N.W.25kgs    

G.W.28kgs 

Paper-drums and two plastic-bags inside.

Storage

Store in cool & dry place.Keep away from strong light and heat.

Shelf life

24 months when properly stored.

What is Tenofovir Disoproxil Fumarate?

 Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. In a T cell line and primary blood lymphocytes, the antiviral activity of tenofovir disoproxil was shown to be more than 100-fold greater than tenofovir because of its rapid intracellular uptake. Tenofovir disoproxil fumarate has been used alone and in various combinations for the prevention and treatment of HIV/AIDS and chronic hepatitis B infections and is on the World Health Organization′s List of Essential Medicines.

Function

1. It is used to treat HIV infection.
2. It is used to treat hepatitis B infection.

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