- Min.Order :1 Metric Ton
- Purity: 99.3%
- Payment Terms : L/C,D/A,D/P,T/T,
Keywords
Ledipasvir 1256388-51-8 GS-5885
Quick Details
- Appearance:Light yellow powder
- Application:Pharmaceutical intermediates
- PackAge:25kg/fiber drum, sealed package
- ProductionCapacity:10|Metric Ton|Month
- Storage:Seald package, keep away from light
- Transportation:Sealed package, keep away from light
Superiority:
1. Advanced facility and Equipment
2. Competent technical team
3 .Strong R & D support
4,high quality products with high stability
5, Competitive price
5.Customer tailored service
Details:
Ledipasvir (formerly GS-5885) is an experimental drug for the treatment of hepatitis C being developed by Gilead Sciences.[1] It is currently in Phase III clinical trials.[2] It is being studied in combination with other direct-acting antiviral agents that interfere with HCV replication.
Ledipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein.
Ledipasvir is being tested in interferon-free regimens with other direct-acting antiviral agents for hepatitis C.
Data presented at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013 showed that a triple regimen of the nucleotide analogue inhibitor sofosbuvir, ledipasvir, and ribavirin produced a 12-week post-treatment sustained virological response (SVR12) rate of 100% for both treatment-naive patients and prior non-responders with HCV genotype 1.[3][4] Gilead is developing a sofosbuvir + ledipasvir coformulation that is being tested with and without ribavirin.
Specification
|
Test
|
Specification
|
Result
|
|
Appearance
|
White to tinted(tan, yellow or pink) powder
|
Light yellow powder
|
|
Identification
|
IR: The IR absorption spectrum of the sample must be concordant with standard substance.
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Conforms
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|
HPLC: The HPLC spectrum of the sample must be concordant with the standard substance.
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Conforms
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Water
|
NMT 0.5%
|
0.26%
|
|
Residue On Ignition
|
NMT 0.1%
|
0.07%
|
|
Heavy Metals
|
NMT 20ppm
|
Conforms
|
|
Acetone Content
|
5.1%~7.1%
|
6.8%
|
|
Residual Solvents
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Acetonitrile: NMT 0.041%
|
N.D.
|
|
Ethyl Acetate: NMT 0.5%
|
N.D.
|
|
|
Related Substances
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Any other impurity: NMT 0.3%
|
0.16%
|
|
Total impurities: NMT 1.0%
|
0.23%
|
|
|
Assay(On anhydrous and solvent free dry basis)
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98.0%~102.0%
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99.72%
|
|
Storage
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Store in a tightly closed container in a cool and dry place, below 20℃.
|
|
|
Conclusion
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Confirm to enterprise standard
|
|
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