Clobetasol Propionate 25122-46-7 Temovate
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Products Name:Clobetasol Propionate
Assay: 99%
Cas: 25122-46-7
Appearance: White crystalline powder
Clobetasol propionate is used for the treatment of various skin disorders
including eczema, psoriasis, and lichen sclerosus.
It is also used to treat several autoimmune diseases including alopecia areata, vitiligo,
lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma).
Item |
Specification |
Result |
Appearance |
White to cream, crystalline powder |
White crystalline powder |
Identification (by IR) |
Conforms to the CRS spectrum |
Conforms |
Melting Point |
Approximately 196 °C |
196°C |
Specific rotation |
+98°~+104°(dried substance) |
+99.7° |
Loss on drying |
≤2.0% |
0.20% |
Residue on ignition |
≤0.1% |
0.06% |
Heavy metals |
≤20ppm |
Conforms |
Related substance (by HPLC) |
Any impurity ≤1.0% |
0.22% |
Total impurities ≤2.0% |
0.31% |
|
Assay(by HPLC) |
Contains 97.0% to 102% of C25H32CIFO5 calculated on dried basis |
99.90% |
Residual solvents |
Ethanol ≤3000ppm |
262ppm |
Aceton ≤500ppm |
Undetected(LOD 4ppm) |
|
Pyriding ≤100ppm |
Undetected(LOD 3ppm) |
|
N,N-Dimethylformamide ≤100ppm |
Undetected(LOD 10ppm) |
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