Bisacodyl

Drug: Bisacodyl

Specification:

Bisacodyl is a diphenylmethane derivative used to empty the bowels before surgery and examinations such as X-ray procedures using barium enemas. It functions as a stimulant laxative and is typically prescribed for relief of constipation and for the management of neurogenic bowel dysfunction.

CAS NO. : 603-50-9

EINECS NO.: 210-044-4

Molecular Formula: C22H19NO4

Molecular Weight: 361.39 g/mol

Physical State: White crystalline powder

Melting Point: 131 - 135 degree C

Properties: In common with other stimulant laxatives, bisacodyl (which is of a related structure to phenolphthalein) stimulates accumulation of water and electrolytes in the colonic lumen and enhances intestinal motility. It may stimulate sodium/potassium-ATPase which may account for a portion of its laxative activity. It may also increase the synthesis of prostaglandins and cyclic-AMP, and this may contribute to increased secretion of water and electrolytes. Bisacodyl is rapidly converted by intestinal and bacterial enzymes to its desacetyl metabolite. As much as 5% of an oral dose is absorbed and excreted in the urine as the glucuronide. This inactive metabolite is also excreted in the bile and may be hydrolyzed to active drug in the colon.

Application & Uses: Used to empty the bowels before surgery and examinations such as X-ray procedures using barium enemas