Gefitinib Iressa 184475-35-2
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Gefitinib | CAS 184475-35-2 | Brand: HLT |
MW:446.9 | MSDS: Avaiable | |
MF:C22H24ClFN4O3 | Sample: Avaiable | |
Category: API | Min order: 10grams | |
Quality standard: 99.50% Purity | Place of Origin:China | |
Usage: | Gefitinib is an EGFR (epidermal growth factor receptor)-tyrosine kinase inhibitor and has been shown to increase phosphorylation of c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. Studies suggest that Gefitinib can enhance keratinocyte apoptosis via an EGFR-independent JNK-activation pathway. Research indicates that Gefitinib can induce apoptosis in several cell lines including, HaCaT cells, KG-1, P39, and primary CD34+ myeloblasts. Erlotinib (sc-202154) has similar properties to Gefitinib. | |
Applications | Pharmaceutical raw materials |
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