Factory supply Glic...

Factory supply Gliclazide
Factory supply Gliclazide
Factory supply Gliclazide
Factory supply Gliclazide
Factory supply Gliclazide

Factory supply Gliclazide

Min.Order / FOB Price:Get Latest Price

1 Metric Ton

FOB Price:USD 1.0000 -2.0000

  • Min.Order :1 Metric Ton
  • Purity: 99%
  • Payment Terms : L/C,T/T,Other

Keywords

Gliclazide 1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-(p-tolylsulfonyl)urea 1-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea

Quick Details

  • Appearance:White powder
  • Application:Gliclazide is mainly used for the onset of adult onset diabetes, which is ineffective with diet control and without ketosis. It can also improve diabetic retinopathy and metabolic and vascular dysfunc
  • PackAge:25 kg/barrels
  • ProductionCapacity:500|Metric Ton|Week
  • Storage:Store in a cool, ventilated warehouse. Keep away from fire and heat. Keep the container sealed
  • Transportation:sea transportation

Superiority:

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environmental protection safety smooth" call and support form, the bold innovation on traditional production equipment and technology, using "high temperature alkali type production method" and "plastic basin of crystallization technology, on the basis of reducing the product cost make the product quality to achieve the same industry leading level.In the company all staff's efforts, in shandong, henan province guangdong South America Europe the United States for decades in Mexico, Brazil, South Africa, Zimbabwe and other places set up several partners, quality inspection department in the company, under the close supervision of a production and sales in the form of "label", provide the fastest speed convenient service for users across the country.

In "advancing with The Times, and the city every day, with the advancement of" under the guidance of the core ideas, adhering to the "relying on scientific and technological innovation, the development of circular economy" of the enterprise purpose, established in the market, enhance strength, go the way of scientific and sustainable development of environmental protection, relying on the national technology research and development center, increasing spending on research and development based on the domestic market, expand the international market, manufacturing high quality products, sincere service society, toward a modern, ecology, science and technology of the domestic first-class, the world's advanced chemical enterprises

 

Details:

Pharmacologic action editing
This product is the second generation of sulfonylurea oral hypoglycemic agents, and it has hypoglycemic effect on both normal and diabetic patients. The hypoglycemic intensity was between methanesulfide and glibenclamide. This product mainly acts directly on the pancreas, promotes the transport of Ca++ to pancreatic beta cells and stimulates insulin secretion. At the same time, it can also improve the metabolism of glucose around the surrounding tissues, thereby reducing blood sugar.
 
In addition, this product can inhibit the release of arachidic acid from platelets from phospholipids, thus reducing the synthesis of thromboxane (TXA3) and also inhibiting the various coagulation factors (such as V, VIII, etc.), and can increase the level of fibrinolytic enzyme activator and promote the dissolution of fibrous egg white. Animal experiments also found that this product can reduce the level of plasma cholesterol, triglycerides and fatty acids.
 
4 pharmacodynamic editors
Promote pancreatic islet B cells to secrete insulin, a prerequisite is that the islet B cells have a certain function of synthesis and secretion of insulin; by increasing the level of insulin in the portal vein or by direct action of the liver, inhibiting the liver glycogen decomposition and gluco isogenesis, hepatogenesis and output of glucagon, and the increase of the external pancreatic tissue to the pancreas. Isomer sensitivity and carbohydrate utilization (probably after receptor action).
 
Therefore, the overall role is to reduce fasting blood glucose and postprandial blood glucose. The absorption rate was fast, and the peak concentration reached 2~6 hours after oral administration for 24 hours. T1/2 for 10~12 hours, mainly through liver metabolism loss of activity, second days can drain 98%. The oral absorption was rapid, the peak time of blood drug concentration was 2 ~ 4h, the binding rate of plasma protein was 85% ~ 87%, the time of maintenance was 24h, and the half period of serum was 10 ~ 12h. Most of this product was metabolized by the liver into an inactive metabolite in the body. After 1 days, 59% was excreted with urine. A small amount was excreted with feces, and 95% of the kidney was excreted in 5 days.

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