GMP Manufacture Supply 99% High purity Ambrisentan CAS 177036-94-1 For Treatment of Pulmonary Hypertension BP/USP

Details:

Introduction

English Generic Name: Ambrisentan

Chinese Pinyin Name: anlishengtan

Chemical Name: (S)-2-(4,6-dimethyl-pyrimidin-2-yl)oxyl-3-methoxyl-3,3-diphenyl propionic acid

Product Code: 0414001

Product Specification: raw medicine

Standard Batch: 600g-700g/Batch

Chemical Structure:

Structural Formula:

Molecular Formula:C₂₂H₂₂N₂O₄

Molecular Weight: 378.42

Descriptions:

Ambrisentan (Letairis) is a selective endothelin receptor A (ETAR) antagonist developed by American Myogen Bio-pharmaceutical Corporation. Its chemical name is (+)-(S)-2-(4,6-dimethyl-pyrimidin-2-yl)oxyl-3-methoxyl-3,3-diphenyl propionic acid. Ambrisentan tablet can strongly inhibit vasoconstriction caused by endothelin. Approved by FDA on June 15, 2007, the drug can be taken orally to treat Pulmonary Arterial Hypertension (PAH).

At present, the drug belongs to original imported product, and the company is only declarer in China. Through improvement of production technology of Ambrisentan raw medicine, the company enhances efficiency, reduce cost and keeps domestically-leading position.

 Physicochemical Property:

The drug is odorless yellowish crystalline powder, easily soluble in dimethylsulfoxide, methyl alcohol and trichloromethane, soluble in dichloromethane, 0.1mol/L sodium hydroxide solution and absolute ethyl alcohol, sparingly soluble in acetonitrile, isopropyl alcohol and acetone, slightly soluble in ethyl acetate, and hardly soluble in water, 0.1mol/L hydrochloric acid solution and n-hexane.

Quality Standard

In line with quality Standard for Declaration.

 Application

Ambrisentan tablet can strongly inhibit vasoconstriction caused by endothelin. Approved by FDA on June 15, 2007, the drug can be taken orally to treat Pulmonary Arterial Hypertension (PAH).

Packaging specification

Internal packaging is heat-sealed single-layer polyethylene plastic bag. External packaging uses vacuumed heat-sealed aluminum foil bag.

Packaging specification: 600-700g/Batch

Storage: sealing

Validity: 24 months (tentative)