Menadione Manufacturer 58-27-5 Food Additives

Min.Order / FOB Price:Get Latest Price

10 Gram	Negotiable

10 Gram

Negotiable

Min.Order :10 Gram
Purity: 99%
Payment Terms : T/T,

Keywords

99% Menadione Menadione Manufacturer Feed Additives , Food Additives

Quick Details

Appearance:White Powder
Application: It Can Be Used As Pharmaceutical Intermediates, Or As Curing Agent Of Epoxy Resins, Etc
PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
ProductionCapacity:10000|Metric Ton|Month
Storage:Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

Superiority:

Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.

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4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

Details:

Menadione Basic information

Chemical properties Application Production

Product Name:	Menadione
Synonyms:	usafek-5185;VitaminK0;β-Methyl-1,4-naphthoquinone;Menadione (1.05793);MENADIONE, USP;MENADIONE (K3) 1000MG NEAT;(MENADIONE)VITAMIN K3, 98+% USP;VITAMIN K3(FEEDSTUFF GRADEMSB96)
CAS:	58-27-5
MF:	C11H8O2
MW:	172.18
EINECS:	200-372-6
Product Categories:	Biochemistry;Vitamins;Nutritional fortification substances;Vitamins and derivatives;Vitamin Ingredients;Miscellaneous Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;RUMENSIN;Isolabel;Other APIs;Inhibitors;feeding additive raw materials
Mol File:	58-27-5.mol

Menadione Chemical Properties

Melting point	105-107 °C(lit.)
Boiling point	262.49°C (rough estimate)
density	1.1153 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	Store at RT.
solubility	oil: soluble
form	crystalline
color	yellow
Water Solubility	INSOLUBLE
Sensitive	Light Sensitive
Merck	14,5831
BRN	1908453
Stability:	Stable. May be light sensitive. Incompatible with strong oxidizing agents.
InChIKey	MJVAVZPDRWSRRC-UHFFFAOYSA-N
CAS DataBase Reference	58-27-5(CAS DataBase Reference)
NIST Chemistry Reference	Menadione(58-27-5)
EPA Substance Registry System	1,4-Naphthalenedione, 2-methyl-(58-27-5)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38-43
Safety Statements	26-36-37/39-24
WGK Germany	3
RTECS	QL9100000
F	8
TSCA	Yes
HazardClass	IRRITANT
Hazardous Substances Data	58-27-5(Hazardous Substances Data)
Toxicity	LD50 orally in mice: ~0.5 g/kg (Molitor, Robinson)

Menadione Usage And Synthesis

Chemical properties	It appears as white crystalline or crystalline powder, being almost odorless and hygroscopic. Its color will change in case of light. It is easily soluble in water, slightly soluble in ethanol, but insoluble in ether and benzene.
Application	Biochemical research; clinical drugs belong to fat-soluble vitamins; it is clinically used as a hemostatic drug. Vitamin K3 is mainly used as poultry feed enhancer at a dosage of 1-5mg/kg. The goods can have addition reaction with sodium bisulfite to generate vitamin K3. VK3. Used as raw material of feed additives; it can mainly promote the liver synthesis of prothrombin in livestock and poultry, and promote the liver synthesis of plasma coagulation factors as a hemostatic agent. Traits: bright yellow crystal with very spicy smell. It is stable in the air and will be decomposed in sunlight. 1G can be dissolved in about 60ml ethanol, 10ml benzene and 50 ml vegetable oil. It is soluble in chloroform and carbon tetrachloride but insoluble in water. The ethanol solution was neutral to litmus paper. The solution will not be decomposed even when heated to 120 °C. It will be destroyed upon treatment with alkali and reducing agent. It is toxic with the half lethal dose (mouse, oral) being about 500 mG/kG. It is irritating. Its commodities still include sodium bisulfite manaquinone, appearing as white crystalline powder. It has no smell or with slightly special smell. It has hygroscopicity. It undergoes decomposition in case of light to turn into yellow or purple color. It is easily soluble in water, slightly soluble in ethanol, but almost insoluble in ether and benzene. Application: biochemical research
Production	There are two production processes. 1. Methyl naphthalene is obtained from the oxidization of chromic anhydride. 2-methyl naphthalene is dissolved in glacial acetic acid, stirred and cooled to temperature below 40 ℃. Slowly add the mixture of chromic anhydride and the same amount of water so that the temperature can be maintained at 35-40 ℃. After the completion of the addition, maintain the temperature at 40 ℃ for 0.5 h, the temperature was then raised to 70 ℃ for 45min, and further heated to 85 ℃ for 15min. Pour the reactants into a lot of water and stir continuously to precipitate out the 2-naphthoquinone. Filter and rinse the filter cake repeatedly with water, until the aqueous solution has no sour. Filter to get the 2-menenoquinone with a yield of 51%. 2-methyl naphthalene can also be made from sodium dichromate and potassium dichromate with the oxidation yield being roughly the same. 2. Cyclohexanone has cyclization reaction with butadiene to get 2-methyl naphthalene hydroquinone, followed by oxidation with chromic acid to obtain the final product. Dissolve the toluquinone in glacial acetic acid; send the butadiene to the required amount at temperature below 20 ℃; stand for 20 hours; heat to release the remaining butadiene and continue to heat to about 110 °C for refluxing of 3 hours. Then recycle 30% of glacial acetic acid through vacuum distillation and cooled to temperature below 40 ℃; slowly add the mixture of chromic acid and the same amount of water so that the temperature is maintained at 65-70 ℃. After the completion of the addition, maintain the temperature at 70-80 degree for 1h to obtain the menadione. O-methyl naphthoquinone is used as raw material. It undergoes oxidation with glacial acetic acid and chromic anhydride, followed by addition with sodium bisulfite in ethanol to derive it.
Chemical Properties	Bright yellow crystals
Uses	Precursor to verious types of Vitamin K. Used as a micronutrient for livestock and pet foods.
Uses	prothrombogenic agent
Uses	antibacterial
Uses	The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
Definition	ChEBI: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group.

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