CAS : 83-43-2 Methylprednisolone for Arthritis
Introduction
English name: Methylprednisolone
Molecular Formula:C22H30O5
Molecular Weight:374.4706
CAS Registry Number:83-43-2
EINECS:201-476-4
Quality:BP/CP
Density:1.28g/cm3
Melting point:228-237°C (dec.)
Boiling point:571.8°C at 760 mmHg
Refractive index:1.602
Flash point:313.7°C
Vapour Pressur:1.86E-15mmHg at 25°C
Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug. It is marketed in the USA and Canada under the brand names Medrol and SoluMedrol.It is also available as a generic drug.It is a variant of prednisolone, methylated at carbon 6 of the B ring.
Specification
Items
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Specifications
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Results
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Appearance
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White Crystalline Powder
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Identification
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Infared Absorption
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Complies
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The retention time of the major peak
in the chromatogram of the
Assay prepration corresponds to that in
the chromatogram of the standard preparation,
as obtained in the assay
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complies
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Specific rotation
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Between -28.6°and -35.0°, measured at 20°
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-32.8°
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Water
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not more than 0.5%
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0.12%
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residue on ignition
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not more than 0.2%
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0.11%
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Heavy metals
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not more than 0.001%
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complies
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related compounds by HPLC(Test1)
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Fructose not more than 0.3% Compound
A not more than 0.3% Other individual impurity not more than 0.1%
Total impurities not more than 0.5%
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Fructose: 0.03% Compound A: 0.04%
Total impurities: 0.07%
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Particle size
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90% less than 350 microns
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complies
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Limit of sulfamate and sulfate
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Sulfamate ion not more than 0.10%
Sulfate ion not more than 0.10%
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complies
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Residual Solvent
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Methylene Chloride not more than 250μg/g
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not detected
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Acetone not mor than 2500μg/g
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Isopropanol not more than 5000μg/g
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Ethanenitrile not more than 400μg/g
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n-hexane not more than 290μg/g
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Ethyl Acetate not more than 2500μg/g
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Pyridine not more than 100μg/g
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Assay
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Topiramate contains not less than 98.0% and
not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis
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99.80%
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Conclustion
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The material complies with respect to USP32
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Function
1-Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory effects;
2-Methylprednisolone is also prescribed for nonpenetrating spinal cord injuries;
3-Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases;
4-Methylprednisolone can also used for vestibular neuritis;
5Methylprednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity