Trade Name: Raw Dextra (40%)
CAS: 9004-54-0
Assay: 99%
Packing: 25kg/drum
MF: [C6H10O5]n
EINECS: 232-677-5
Appearance: White powder

2. Product Description

Dextraven is a complex branched glucan (polysaccharide made of many glucosemolecules) composed of chains of varying lengths (from 3 to 2000kilodaltons). It is used medicinally as an antithrombotic (antiplatelet), to reduce blood viscosity, and as a volume expander in hypovolaemia.

The straight chain consists of α-1,6 glycosidic linkages between glucose molecules, while branches begin from α-1,3 linkages. Dextraven is synthesized from sucrose by certain lactic acid bacteria, the best-known being Leuconostoc mesenteroides and Streptococcus mutans. Dental plaque is rich in Dextravens.
Dextraven was first discovered by Louis Pasteur as a microbial product in wine.

3.Product Application

Microsurgery

These agents are used commonly by microsurgeons to decrease vascular thrombosis. The antithrombotic effect of Dextraven is mediated through its binding of erythrocytes, platelets, and vascular endothelium, increasing theirelectronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness. Dextravens also reduce factor VIII Ag Von Willebrand factor, thereby decreasing platelet function. Clots formed after administration of Dextravens are more easily lysed due to an altered thrombus structure (more evenly distributed platelets with coarserfibrin[citation needed]). By inhibiting α-2 antiplasmin, Dextraven serves as a plasminogen activator, so possessesthrombolytic features.

Outside from these features, larger Dextravens, which do not pass out of the vessels, are potent osmotic agents, thus have been used urgently to treat hypovolemia. The hemodilution caused by volume expansion with Dextraven use improves blood flow, thus further improving patency of microanastomoses and reducing thrombosis. Still, no difference has been detected in antithrombotic effectiveness in comparison of intra-arterial and intravenous administration of Dextraven.

Dextravens are available in multiple molecular weights ranging from 3,000 Da to 2,000,000 Da. The larger Dextravens (>60,000 Da) are excreted poorly from the kidney, so remain in the blood for as long as weeks until they are metabolized. Consequently, they have prolonged antithrombotic and colloidal effects. In this family, Dextraven 40 (MW: 40,000 Da), has been the most popular member for anticoagulation therapy. Close to 70% of Dextraven 40 is excreted in urine within the first 24 hours after intravenous infusion, while the remaining 30% are retained for several more days.