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Sodium levothyroxine 25416-65-3 Sodium levothyroxine 25416-65-3
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Product Description
l-tyrosine,o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt, hydrate (9ci)
name:l-tyrosine,o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt, hydrate (9ci)
einecs:200-221-4
molecular formula:c15h10i4nnao4.xh2o
cas registry number:25416-65-3
synonyms:levo-tiroxina glaxo; monosodium l-thyroxine hydrate;
appearance:gray to yellow powder
molecular weight:798.86
density:g/cm3
boiling point:576.3 °c at 760 mmhg
melting point:207-210 oc
standard:gp standard
assay:98%
package:1kg/al bag
Certificates of Analysis
|
specification |
result |
|
appearance |
an odorless, almost white or buff colored powder |
pass |
|
solubility |
1,very slightly soluble in water |
pass |
|
2,slightly soluble in alcohol |
pass |
||
3,practically insoluble in most other organic solvents |
pass |
||
4,disolves in diluted aqueous sodium hydroxide solutions |
pass |
||
identification |
a) heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved. |
pass |
|
b)the retention time of the major peak is confirm to the rs |
pass |
||
loss on drying |
not more than 4.0% |
0.46% |
|
|
|
+20.9o |
|
assay(hplc) |
not less than 95.0% |
99.70% |
|
levothyroxine sodium |
not more than 5.0% |
0.68% |
|
conclusion: |
up to the standard for export |
Function&Application
levothyroxine (inn, usan) or l-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (t4), which is naturally secreted by the follicular cells of the thyroid gland. it is used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. like its naturally secreted counterpart, levothyroxine is a chiral compound in the l-form. the related drug dextrothyroxine (d-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated
cholesterol levels) but was withdrawn due to cardiac side effects. it is on the world health organization's list of essential medicines, a list of the most important medication needed in a basic health system.
levothyroxine (inn, usan) or l-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (t4), which is naturally secreted by the follicular cells of the thyroid gland. it is used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. like its naturally secreted counterpart, levothyroxine is a chiral compound in the l-form. the related drug dextrothyroxine (d-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated
cholesterol levels) but was withdrawn due to cardiac side effects.
levothyroxine is typically used to treat hypothyroidism, and is the treatment of choice for patients with hypothyroidism, who often require lifelong thyroid hormone therapy. it may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (tsh), a hormone that is considered goiter-inducing. levothyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (tsh) secretion.
applications :
levothyroxine is typically used to treat hypothyroidism,and is the treatment of choice for patients with hypothyroidism, who often require lifelong thyroid hormone therapy.it may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (tsh), a hormone that is considered goiter-inducing.levothyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (tsh) secretion.
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