Tianeptine Sodium 30123-17-2 Tianeptine
Tianeptine Sodium Basic Info:
Item | Specifications | Results |
Assay(HPLC) | 98.0%~102.0% | 98.9% |
Appearance | Off-white crystalline powder | Complies |
Identification | IR | Complies |
Melting point | 156.0~160.0℃ | 157.0~158.0℃ |
Loss on drying | ≤0.5% | 0.11% |
Residue on ignition | ≤0.1% | 0.06% |
Related substance | ≤1.0% | 0.75% |
Heavy metals | ≤10ppm | Complies |
What is Tianeptine Sodium
Tianeptine sodium salt is a salt of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake . Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptine in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation.
Tianeptine Sodium Benefit:
Tianeptine Sodium Function & Application:
Tianeptine is antidepressant. The animal has: the hippocampus pyramidal cells increased spontaneous activity, and accelerating its function was inhibited after recovery; increase in cortical and hippocampal neurons at sites of 5- serotonin reuptake. Tianeptine without following adverse effects: sleep and alertness; cardiovascular system; cholinergic system ( without anticholinergic symptoms ); drug craving.
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