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10 Gram |
Negotiable |
Voriconazole Voriconazole Powder Voriconazole 99%
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Product Name: | Voriconazole |
CAS: | 137234-62-9 |
MF: | C16H14F3N5O |
MW: | 349.31 |
EINECS: | 200-261-5 |
Product Categories: | Fine Chemical;antifungal;API;Antifungal (Systemic);Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles;Pfizer compounds;Inhibitor;ZINACEF |
Mol File: | 137234-62-9.mol |
Voriconazole is an ergosterol biosynthesis inhibitor, as well as systemic antifungal. This compound, like many antifungal agents, is an inhibitor of CYP2C9, an enzyme involved in the oxidative metabolism of many xenobiotics. Voriconazole is an inhibitor of CYP51A1.
Items
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Specifications
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Results
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Appearance
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White to off-white powder
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White powder
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Solubility
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Freely soluble in dichloromethane and acetone; soluble in methanol and trichloromethane; slightly soluble in water
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Complies
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Identification
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||
(1) IR
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Sample IR spectrum corresponds to that of the standards
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Complies
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(2) HPLC
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The retention time of the major peak of the sample solution corresponds to that of the standard solution, as obtained in the assay
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Complies
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Test
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Triazole acetophenone: ≤0.12%
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Not detected
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Ethyl fluropyrimidine: ≤0.12%
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0.10%
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Voriconazole related compound A: ≤0.12%
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Not detected
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Related substance
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(RR,SS)6- Chlorovoriconazole: ≤0.12%
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0.09%
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6- Chlorovoriconazole: ≤0.12%
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0.09%
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Any unspecified impurity: ≤0.1%
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0.08%
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Total impurities:≤0.5%
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0.40%
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Heavy Metal
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NMT 10ppm
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<10ppm
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Residue on ignition
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NMT 0.1%
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0.06%
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Enantiomeric purity
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Voriconazole related compound B: ≤0.12%
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Not detected
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Loss on Drying
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NMT 0.5%
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0.04%
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Trichloromethane
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NMT 60ppm
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Not detected
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Dichloromethane
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NMT 600ppm
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Not detected
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Methanol
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NMT 3000ppm
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Not detected
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2-propanol
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NMT 5000ppm
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200ppm
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Acetone
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NMT 5000ppm
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Not detected
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Assay( on dried basis )
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98.0%~102.0%
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99.40%
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Conclusion
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Complies with the specification
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a. It is a triazole antifungal medication, it can cure empirical antifungal therapy.
b. It has become the new standard of care in the treatment of invasive aspergillosis.
c. It can used in the treat of esophageal candidiasis.
d. It has also been used to treat severe fungal corneal infection.
e. An antifungal (systemic). An ergosterol biosynthesis inhibitor.
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