Metronidazole material supplier low price

Details:

Metronidazole

CAS: 443-48-1

Purity: 99%

 

Pharmacology and mechanism of action

Metronidazole is a 5-nitroimidazole derivative which was originally introduced against Trichomonas

vaginalis in 1960. Soon it was shown to possess a broad spectrum of activity against other protozoal

infections such as amoebiasis and giardiasis, and more recently against infections due to anaerobic

bacteria . The mechanism of action of metronidazole is not well understood. In the parasite, the 5-nitro

group of the drug undergoes reductive transformation to a cytotoxic intermediate which binds to the

helical structure of the DNA leading to strand breakage and eventual cell death.

 

Indications and Usage

Metronidazole is a nitroimidazole antibiotic, also known as metronidazol and novonidazol. It was initially

used to treat vaginal trichomaniasis, with very significant clinical effects. It is broadly used to prevent and

treat oral anaerobic infections.

 

In hospitals, it has been used frequently to prevent and treat respiratory, gastrointestinal, peritoneal, pelvic,

skin, soft tissue, joint, and brain infections, cardiomyitis, and septicemia caused by anaerobic bacteria. The

effectiveness of Metronidazole towards treating body tissue and intestinal amoebiasis is significant, and it

the preferred drug to treat parasitosis.

 

Side effects

Side effects with doses used to treat protozoal infections are usually mild, reversible and self-limiting and

may affect 4% to 5% of treated patients. The most common are gastrointestinal disturbances (nausea,

vomiting, epigastric pain, metallic taste, furring of the tongue), intolerance to alcohol (disulfiram-like effect)

and central nervous system effects (headache, dizziness and sleepiness) . Other side effects reported

include urticaria, darkening of the urine with a reddish-brown discoloration and transient neutropenia .

During prolonged high doses, the drug may cause severe neurotoxic side effects such as peripheral

neuropathy, paraesthesia and epileptiform seizures . Few case reports of bone marrow depression,

gynecomastia and acute pancreatitis have been reported. Although metronidazole is mutagenic in

bacteria and carcinogenic in rodents, no association with human cancer has been proven .

 

Package

25KG/drum

1kg/foil bag

 

Storage

2-8°C

 

Related pictures

Wuhan Xinru Chemical Industry Co.,Ltd founded in 2006, engaged in R&D, producing

and marketing barium salts, sodium salts, fertilizer and pharmaceutical intermediates.

 

Xinru Chemical has several stock-holding factories, based on strong R&D ability, advanced

production technology and experienced team; pluses international trade office in Wuhan, we

can offer high and stable quality products with quick response and service.

 

From 2006,we have already developed and established a very good relationship with different

reputed customers in EU, Egypt, Canada, Korea, USA, Chile, Turkey, Thailand etc.Our products

widely used in water purification,magnet material, rubber, ceramic,glass,painting, powder coating,

plastic industry, pharmacy and so on.