Abiraterone / Abira...

Abiraterone / Abiraterone Intermediates

Abiraterone / Abiraterone Intermediates

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10 Gram

Negotiable

  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : T/T,

Keywords

Abiraterone Intermediate Abiraterone Intermediate powder CAS 154229-19-3

Quick Details

  • Appearance:white powder
  • Application:Abiraterone (CB-7598, CB7598, CB 7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone is used in treatment of prostate cancer
  • PackAge:aluminum foil bag
  • ProductionCapacity:100|Kilogram|Month
  • Storage:cool and dry place
  • Transportation:email: wonda-chem@outlook.com

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1.high quality:

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2.reasonable price:

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3.low moq:

no worry about the low moq, our moq is 1 gram or even lower.

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Details:

Description                                           

Product Name:Abiraterone

CAS No .154229-19-3

Formula:C24H31NO 

Molecular Weight:1202.84 

CAS No.154229-19-3

Density:1.016 g/cm3

Melting Point:148-151°C

Boiling Point:1293.8 °Cat 760 mmHg

Flash Point:736.3 °C

Solubility:ethanol: 30 mg/mL

Appearance:White Powder

Introduction                                          

Abiraterone (CB-7598, CB7598, CB 7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone is used in treatment of prostate cancer.

Abiraterone is the active metabolite of abiraterone acetate, which is an orally active acetate ester of the steroidal compound abiraterone with antiandrogen activity. Abiraterone acetate was approved by the U.S. Food and Drug Administration (FDA) in April 2011. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. Abiraterone is a drug used in castration-resistant prostate cancer (formerly hormone-resistant or hormone-refractory prostate cancer) -- i.e., prostate cancer not responding to androgen deprivation or treatment with antiandrogens. It is formulated as the prodrug abiraterone acetate and marketed under the trade name Zytiga.

COA                                                       

Items

Specifications

Results

Appearance

White or off-white solid

Complies

Identification

H-NMR

Complies

Melting point

223-233°C

224.3-226.2°C

Loss on drying

no more than 1.0%

0.5%

Residue on ignition

<0.2%

0.07%

Purity (HPLC)

no less than 99.0%

99.6% 

 

 

 

 

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