3H-1,2,4-Triazole-3-thione, 1,2-dihydro-1-methyl-

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Preparation of 3-[(2-dimethylaminobenzyl)thio-,- sulfinyl-, and -sulfonyl]triazoles as antiulcer agents

Marton Meresz, Magdolna; Kuszmann, Janos; Andrasi, Ferenc; Berzsenyi, Pal; Sebestyen, Laszlo; Moravcsik, Imre; Sziraki, Istvan (Gyogyszerkutato Intezet, Hung.). PCT Int. Appl. WO 9513268 A1 18 May 1995, 33 pp. DESIGNATED STATES: W: AT, AU, BB, BG, BR, BY, CA, CH, CZ, DE, DK, ES, FI, GB, JP, KP, KR, KZ, LK, LU, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, US, VN; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG. (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D249-12. APPLICATION: WO 93-HU63 12 Nov 1993. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Title compds. [I; R = CH2C6H4(NMe2)-2][II; 1 of Z1,Z2 = CR1 and the other = N; R1,R2 = H, alk(en)yl, (un)substituted Ph; n = 0-3] were prepd.Several substances like 29983-22-0 may be metioned in this study. Thus, 4,5-dimethyl-1,2,4-triazole-3-thiol was condensed with ClCH2C6H4(NMe2)-2 and the product treated with 3-ClC6H4CO3H to give II (R2 = Me, Z1 = N, Z2 = CMe, n = 1) which had ED50 of 2.8 and 2.6mg/kg orally based on no. and severity, resp., of reserpine-induced ulcers in rats.