Side chain for meropenem Meropenem CAS 96034-64-9
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Introduction
English name: | Meropenem |
Synonyms: |
4r,5s,6s)-3-[[(3s,5s)-5-dimethylcarbamoylpyrrolidin-3-;(4r,5s,6s) -3-[[(3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio]-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2 -carboxylic acid;)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl -7-oxo-,(4r-(3(s*,5s*),4-al;5-beta,6-beta(r*)))-ph; |
CAS NO.: | 96036-03-2 |
Appearance: | white crystalline powder |
Molecular weight: | 383.46 |
Molecular formula: |
C17H25N3O5S |
Function: | Antinfective |
Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem, similar to imipenem and ertapenem.
Function
The spectrum of action includes many Gram-positive and Gram-negative bacteria (including Pseudomonas) and anaerobic bacteria. The overall spectrum is similar to that of imipenem, although meropenem is more active againstEnterobacteriaceae and less active against Gram-positive bacteria. It is also very resistant to extended-spectrum beta lactamases but may be more susceptible to metallo-beta-lactamases. Meropenem is frequently given in the treatment of febrile neutropenia. This condition frequently occurs in patients withhematological malignancies and cancer patients receiving anticancer drugs that cause bone marrow suppression. It is approved for complicated skin and skin structure infections, complicated intra-abdominal infections and bacterial meningitis.
Specification
Items |
Specification |
Results |
|
Appearance |
White or off-white powder |
Conformed |
|
Identification |
Meets the requirements |
Conformed |
|
pH |
7.3-8.3 |
8.07 |
|
Loss on drying |
9.0%~12.0% |
10.2% |
|
Chromatographic |
RRT(0.45) |
0.80% MAX |
0.13% |
purity |
RRT(1.90) |
0.60% MAX |
0.15% |
Particulate matter |
≥10 um |
≤6000 pc/g |
Conformed |
≥25 um |
≤600 pc/g |
Conformed |
|
Uniformity of dosage unites |
Meets the requirements |
conformed |
|
Bacterial endotoxinsunder |
≤0.125EU/mg |
Conformed |
|
Sterility |
Meets the requirements |
Conformed |
|
Content of sodium |
5.3%-8.0% |
6.8% |
|
Assay(C17H25N3O5S) on anhydrous basis |
≥ 76.0% |
80.7% |
|
Conclusion |
The product conforms the USP30 standard |
||
Packing storage |
In tight containers, the dry powder at controlled room temperature |
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