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cadmium bromide cadmium(2+) dibromide Cadmiumbromide (8CI)
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Details:
| Name |
Chloropropamide |
EINECS | 202-314-5 |
| CAS No. | 94-20-2 | Density | 1.334 g/cm3 |
| Solubility | Insoluble in water | Melting Point | 128 °C |
| Formula | C10H13ClN2O3S | Boiling Point | |
| Molecular Weight | 276.76 | Flash Point | |
| Transport Information | Appearance | white crystalline powder | |
| Safety | 22-36 | Risk Codes | 20/21/22-40 |
| Molecular Structure |
 |
Hazard Symbols |
 Xn |
| Synonyms |
Chloropropamide Chemical Properties
IUPAC Name: Chloropropamide
The MF of Chlorpropamide (CAS NO.94-20-2) is C10H13ClN2O3S.
The MW of Chlorpropamide (CAS NO.94-20-2) is 276.74.
Synonyms of Chlorpropamide (CAS NO.94-20-2): 1-(4-chlorophenyl)sulfonyl-3-propyl-urea ; 4-Chlor-N-(propylcarbamoyl)benzolsulfonamid ; Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)- ; Oradian
Appearance: white crystalline powder
Stability: Stable. Combustible
Index of Refraction: 1.552
EINECS: 202-314-5
Density: 1.334 g/ml
Melting Point: 128 °C
Merck: 2186
Chloropropamide Uses
Chlorpropamide (CAS NO.94-20-2) is sulfonylurea oral hypoglycemic agents which mainly selectively act on the pancreatic islet-β-cells, promoting insulin secretion.Chlorpropamide has a relatively large side-effects, so the using of the drug are decreasing trend.
Chloropropamide Production
Chlorobenzene sulfonamide reacts with chlorobenzene sulfonyl amide,generating C urea sodium salt. Then hydrochloric acid, refined to derive. Another method is based on chlorobenzene sulfonamide, isopropyl isocyanate, triethylamine as raw materials.
Chloropropamide Toxicity Data With Reference
| 1. |
sce-mus-orl 177 mg/kg |
MUREAV Mutation Research. 77 (1980),349. | ||
| 2. |
sce-ham-ipr 7100 µg/kg |
MUREAV Mutation Research. 77 (1980),349. | ||
| 3. |
orl-wmn TDLo:25 mg/kg/5D-I:BLD |
DICPBB Drug Intelligence and Clinical Pharmacy. 18 (1984),981. | ||
| 4. |
orl-wmn TDLo:300 mg/kg:CNS |
CTOXAO Clinical Toxicology. 11 (1977),13. | ||
| 5. |
orl-man TDLo:83 mg/kg/25D-I:GIT |
AJGAAR American Journal of Gastroenterology. 80 (1985),381. | ||
| 6. |
orl-rat LD50:2150 mg/kg |
FATOAO Farmakologiya i Toksikologiya (Moscow). 25 (1962),93. | ||
| 7. |
ipr-rat LD50:580 mg/kg |
TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185. | ||
| 8. |
ivn-rat LD50:590 mg/kg |
PMDCAY Progress in Medical Chemistry. 1 (1961),187. | ||
| 9. |
orl-mus LD50:1546 mg/kg |
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 153 (1965),379. | ||
| 10. |
ivn-mus LD50:500 mg/kg |
PMDCAY Progress in Medical Chemistry. 1 (1961),187. |
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