GMP factory supply 99% raw powder Pomalidomide

GMP factory supply 99% raw powder Pomalidomide

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price: USD 1.0000

1 Kilogram

FOB Price: USD 1.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/P,T/T,Other

Keywords

Pomalidomide Pomalidomide powder Pomalidomide factory

Quick Details

Appearance:yellow powder
Application:Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog. An inhibitor of LPS-induced TNFαrelease.
PackAge:carton drum
ProductionCapacity:100000|Kilogram|Month
Storage:Stored in a well-closed container away from moisture and strong light/heat.
Transportation:by sea/air/express

Superiority:

GMP factory supply 99% raw powder Pomalidomide

Basic info

Product Name: Pomalidomide
Synonyms: Pomalidomide high quality;pomalidomide,Pomalyst;Actimid (Celgene);4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;Pomalidomide high quality 19171-19-8;Pomalidomide, 99%, a inhibitor of TNF-α;4-Amino-2-(2,6-dioxo-piperidin-3-yl)-1H-isoindol-1,3(2H)-dione;4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
CAS: 19171-19-8
MF: C13H11N3O4
MW: 273.24
EINECS: 805-902-5
Melting point 318.5 - 320.5°
Boiling point 582.9±45.0 °C(Predicted)
density 1.570±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥14mg/mL
pka 10.75±0.40(Predicted)
form powder
color yellow
Uses Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM
Uses Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
Uses Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog. An inhibitor of LPS-induced TNFαrelease.

Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.
Pomalidomide inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Pomalidomide inhibits the growth of T regulatory cells which is stimulated by IL-2 with an IC50 of ~1 μM. Treatment with Pomalidomide (6.4 nM-10 μM) increases the production of IL-2 in human peripheral blood T cells, and is slightly more potent in the CD4+ subset than in the CD8+ subset. Pomalidomide is significantly more potent than CC-5013 at elevating IL-2, IL-5, and IL-10 levels, but only slightly more potent than CC-5013 at elevating IFN-γ levels.
Pomalidomide enhances SEE and Raji cells induced AP-1 transcriptional activity in Jurkat cells in a dose-dependent manner, with a maximal enhancement of 4-fold at 1 μM. Exposure of Raji cells to various concentrations of Pomalidomide (2.5-40 μg/mL) for 48 hours leads to a significant decrease in cell proliferation and DNA synthesis. There is a reduction of ~40% compared to vehicle-treated controls.

Packing and storage

Packing:25kg carton drum,double-layer plastic bags inside

Sttorage:Sealed in cool and dry place, keep away from strong light and heat.

Shelf life: 24 months when properly stored.

COA and other ceitificates will be sent under request.

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Company Profile

Wuhan Recedar Biotechnology Co., Ltd, located in Donghu high-tech development zone, China, is one of the leading manufacture of natural color and plant extract. We are engaged in research, development, producing and marketing. With our strict quality-control system and years of good reputation, our products are widely used in pharmaceuticals, cosmetics, food, nutrients etc.

Currently,Recedarbio has four production departments (PDs), and more than 200 employees. The company has its own R&D team, complete testing equipments, qualified enviormental protection system in accordance with the national standard, and also has clean production environment.