Reliable quality of 864070-44-0 global trader Empagliflozin Offer

Reliable quality of 864070-44-0 global trader Empagliflozin Offer

Min.Order / FOB Price:Get Latest Price

500 Gram	Negotiable

500 Gram

Negotiable

Min.Order :500 Gram
Purity: 99min
Payment Terms : L/C,D/A,D/P,T/T,

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Reliable quality of 864070-44-0 global trader Empagliflozin Offer Empagliflozin

Quick Details

Appearance:As per Certificate of analysis
Application:For pharmaceutical intermediates and raw materials
PackAge:as your request
ProductionCapacity:500|Kilogram|Month
Storage:Preserve in well closed container, store in a cool and dry place, and keep away from strong light and heat.
Transportation:By air, courier or sea

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Reliable quality of 864070-44-0 global trader Empagliflozin Offer

Product Name: Empagliflozin

Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol

CAS NO.: 864070-44-0

Molecular Formula: C₂₃H₂₇ClO₇

Molecular Weight: 450.91

Molecular Structure:

Specification & COA: Please contact us

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4.Method of Aanlysis (MOA)

5.Nuclear Magnetic Resonance (NMR)

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Empagliflozin Usage And Synthesis

Description Empagliflozin(trade name Jardiance) is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and causes sugar in the blood to be excreted by the kidneys and eliminated in urine. On August 1, 2014, the Food and Drug Administration (FDA) officially approved the drug for the treatment of type 2 diabetes, to improve and control blood glucose of adults. Empagliflozin is the third SGLT-2 inhibiting drugs approved by FDA. Another two SGLT-2 inhibitor drugs, canagliflozin and dapagliflozin, belonging to Johnson Pharmaceuticals, AstraZeneca and Bristol-Myers Squibb respectively, are approved by FDA in November 2013 and January 2014 respectively. The new drug Empagliflozin’s application to FDA can be described as twists and turns. In March 2014, due to a large particle contamination incident at the empagliflozin production plant in Boehringer, the application of new drug submitted by the Boehringer-Eli Lilly Alliance was rejected by FDA. In June 2014, after reviewing the summary and material submitted by Boehring in March, confirming that the quality management and compliance system of the Boehring drug production facility was acceptable, FDA withdrew the previously issued warning letter. The Boehringer-Eli Lilly Alliance also filed an application with the FDA on June 17th.

Details:

Shanghai Rochi Pharmaceutical Co., Ltd. is located in Shanghai Zhangjiang Hi-Tech Biological and Pharmaceutical Innovation Park. It is a high-tech enterprise integrating R&D, production and sales of APIs and intermediates. The company's products mainly involve five major fields: cardiovascular, CNS, hypoglycemic, antiviral and anti-cancer. The company provides customers with one-stop service for project development, from laboratory development, process optimization to commercial production. Available in grams to tonnage grades. The company helps customers shorten the development cycle and cost of new and generic drugs through cost-effective and efficient services.

The company has four production bases, located in Shangrao Jiangxi, Leping Jiangxi, Maanshan Anhui, and Weihai Shandong. The plant equipment can complete the reaction from high pressure 12Mpa to atmospheric pressure reaction, from cryo-100 °C reaction to high temperature +300 °C reaction. The Shandong factory has passed many international official certifications such as the US FDA, EU EDQM, Japan PMDA, and Korea KFDA.

The company's chemical research and development center Roke Bio is located in Anhui Anqing Industrial Park. With a laboratory area of 1,200 square meters, it has 3 R&D laboratories, 3 kg-level laboratories and supporting analysis rooms. At the same time, the company has also established an 800-square-meter biocatalytic laboratory to independently develop and produce biocatalysts for specific reactions to produce hand-type compounds. This technology not only improves the quality of the products, but also is green and environmentally friendly. In order to enhance the company's technology research and development, the company maintains good R&D cooperation relationship with many well-known institutions of higher learning and pharmaceutical research institutes in Shanghai. The company's products are of high quality and excellent quality and are exported to many countries and regions such as Europe, America, India and surrounding areas.

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